ArticleGenes and immunity2006
Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- C1q as a target molecule to treat human disease: What do mouse studies teach us?Frontiers in immunology · 2022Pooled it
- Article
- Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis.BMC immunology · 2014Article
- Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI.Journal of leukocyte biology · 2014Article
- Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.PloS one · 2014Article
- A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.Glycobiology · 2013Article
- Cyclin-dependent kinase inhibitor Cdkn2c deficiency promotes B1a cell expansion and autoimmunity in a mouse model of lupus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Cellular regulation of the inflammatory response.Toxicologic pathology · 2012Review
- NETs: the missing link between cell death and systemic autoimmune diseases?Frontiers in immunology · 2012Article
- The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis.Journal of autoimmunity · 2011Article
- Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22.Frontiers in immunology · 2011Article
- Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.Genes and immunity · 2010Article
- Identification and characterization of a lupus suppressor 129 locus on chromosome 3.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.Genes and immunity · 2009Article
- Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.Arthritis and rheumatism · 2008Article
- Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- CD22: an inhibitory enigma.Immunology · 2008Review
- Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice.Genes and immunity · 2008Article
- Immunological consequences of apoptotic cell phagocytosis.The American journal of pathology · 2007Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Systemic lupus erythematosus is an autoimmune disease in which complex interactions between genes and environmental factors determine the disease phenotype. We have shown that genes from the non-autoimmune strains 129 and C57BL/6 (B6), commonly used for generating gene-targeted animals, can induce a lupus-like disease. Here, we conducted a genome-wide scan analysis of a cohort of (129 x B6)F2 C1q-deficient mice to identify loci outside the C1qa locus contributing to the autoimmune phenotype described in these mice. The results were then confirmed in a larger dataset obtained by combining the data from the C1q-deficient mice with data from previously reported wild-type mice. Both analyses showed that a 129-derived interval on distal chromosome 1 is strongly linked to autoantibody production. The B6 genome contributed to anti-nuclear autoantibody production with an interval on chromosome 3. Two regions were linked to glomerulonephritis: a 129 interval on proximal chromosome 7 and a B6 interval on chromosome 13. These findings demonstrate that interacting loci between 129 and B6 mice can cause the expression of an autoimmune phenotype in gene-targeted animals in the absence of any disrupted gene. They also indicate that some susceptibility genes can be inherited from the genome of non-autoimmune parental strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.