ArticleMolecular and cellular biology2006
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk.Frontiers in immunology · 2020Article
- Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels.Frontiers in immunology · 2019Article
- Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice.Frontiers in immunology · 2019Article
- Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells.Biochimica et biophysica acta · 2016Article
- The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.Blood · 2015Article
- Talin and kindlin: the one-two punch in integrin activation.Frontiers of medicine · 2014Review
- Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.The Journal of clinical investigation · 2014Article
- Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.Blood · 2013Article
- Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets.Thrombosis research · 2012Article
- Blood flow reprograms lymphatic vessels to blood vessels.The Journal of clinical investigation · 2012Article
- The insider's guide to leukocyte integrin signalling and function.Nature reviews. Immunology · 2011Review
- 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.Molecular immunology · 2011Article
- Signaling during platelet adhesion and activation.Arteriosclerosis, thrombosis, and vascular biology · 2010Review
- Adaptor protein is essential for insect cytokine signaling in hemocytes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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- The SYK tyrosine kinase: a crucial player in diverse biological functions.Nature reviews. Immunology · 2010Review
- Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.Cold Spring Harbor perspectives in biology · 2010Review
- Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.The Journal of allergy and clinical immunology · 2009Article
- The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.Immunological reviews · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Syk tyrosine kinase and Src homology 2 (SH2) domain-containing leukocyte-specific phosphoprotein of 76 kDa (SLP-76) are signaling mediators activated downstream of immunoreceptor tyrosine-based activation motif (ITAM)-containing immunoreceptors and integrins. While the signaling cascades descending from integrins are similar to immunoreceptors, the mechanism of Syk activation and SLP-76 recruitment remains unclear. We used an in vivo structure-function approach to study the requirements for the domains of Syk and SLP-76 in immunoreceptor and integrin signaling. We found that both SH2 domains and the kinase domain of Syk are required for immunoreceptor-dependent signaling and cellular response via integrins. While the Gads-binding domain of SLP-76 is needed for immunoreceptor signaling, it appears dispensable for integrin signaling. Syk and SLP-76 also are required for initiating and/or maintaining separation between the blood and lymphatic vasculature. Therefore, we correlated the signaling requirement of the various domains of Syk and SLP-76 to their requirement in regulating vascular separation. Our data suggest ITAMs are required in Syk-dependent integrin signaling, demonstrate the separation of the structural features of SLP-76 to selectively support immunoreceptor versus integrin signaling, and provide evidence that the essential domains of SLP-76 for ITAM signals are those which most efficiently support separation between lymphatic and blood vessels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.