ArticleBiology direct2006
Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires.
Article in Biology direct, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Fast clonal family inference from large-scale B cell repertoire sequencing data.Cell reports methods · 2023Article
- DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification.Science immunology · 2023Article
- Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.PLoS computational biology · 2022Article
- In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Review
- Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies.Cellular & molecular immunology · 2019Article
- Deciphering evolution of immune recognition in antibodies.BMC structural biology · 2018Article
- Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.Frontiers in immunology · 2018Review
- Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.The Journal of biological chemistry · 2014Article
- Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1.Frontiers in immunology · 2014Review
- Secondary mechanisms of diversification in the human antibody repertoire.Frontiers in immunology · 2013Article
- Insertion/Deletion polymorphisms do play any role in G6PD deficiency individuals in the Kingdom of the Saudi Arabia.Bioinformation · 2013Article
- Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity.Genes and immunity · 2012Article
- Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Domain specificity of the human antibody response to Bacillus anthracis protective antigen.Vaccine · 2008Article
- Paratope diversity in the human antibody response to Bacillus anthracis protective antigen.Molecular immunology · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
unlabelledIt has been suggested that codon insertion and/or deletion may represent a mechanism that, along with hypermutation, contributes to the affinity maturation of antibodies. We used repertoire cloning to examine human antibodies directed against 3 carbohydrate antigens and 1 protein antigen for the presence of such modifications. We find that both the insertion and deletion of codons occur frequently in antigen-specific responses following vaccination. Codon insertions and deletions were observed most often in the complementarity determining regions, and less frequently in the framework regions, of VH, Vkappa, and Vlambda gene segments, and involved motifs known to be preferred targets of somatic hypermutation. Clonal lineage analysis shows that these events occur through out the course of the somatic maturation of individual antibody clones. We also determined that these alterations of paratope structure have varying effects on the relative affinity of the binding site for its cognate antigen. REVIEWERS: This article was reviewed by Mark Shlomchik, Deborah Dunn-Walters (nominated by Dr. Andrew Macpherson), and Rachel M. Gerstein. OPEN PEER REVIEW: Reviewed by Mark Shlomchik, Deborah Dunn-Walters (nominated by Dr. Andrew Macpherson), and Rachel M. Gerstein. For the full reviews, please go to the Reviewers' comments section.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.