ArticlePlant molecular biology2006
FW2.2 and cell cycle control in developing tomato fruit: a possible example of gene co-option in the evolution of a novel organ.
Article in Plant molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 104 citations in OpenAlex.
- Article
- Establishment of a Genetic Transformation System forPlants (Basel, Switzerland) · 2026Article
- The CELL NUMBER REGULATOR FW2.2 protein regulates cell-to-cell communication in tomato by modulating callose deposition at plasmodesmata.Plant physiology · 2024Article
- Genome-Wide Analyses ofInternational journal of molecular sciences · 2023Article
- The role of non-additive gene action on gene expression variation in plant domestication.EvoDevo · 2023Article
- The SUMO E3 Ligase MdSIZ1 Sumoylates a Cell Number Regulator MdCNR8 to Control Organ Size.Frontiers in plant science · 2022Article
- Mutation inInternational journal of molecular sciences · 2021Article
- Fruit size control by a zinc finger protein regulating pericarp cell size in tomato.Molecular horticulture · 2021Article
- Modification of cereal plant architecture by genome editing to improve yields.Plant cell reports · 2021Review
- Cis- and Trans-Regulatory Variations in the Domestication of the Chili Pepper Fruit.Molecular biology and evolution · 2020Article
- NMR-Based Tissular and Developmental Metabolomics of Tomato Fruit.Metabolites · 2019Article
- Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair.Scientific reports · 2019Article
- The Maize MID-COMPLEMENTING ACTIVITY Homolog CELL NUMBER REGULATOR13/NARROW ODD DWARF Coordinates Organ Growth and Tissue Patterning.The Plant cell · 2017Article
- PTIR: Predicted Tomato Interactome Resource.Scientific reports · 2016Article
- Light- and temperature-regulated BjAPY2 may have a role in stem expansion of Brassica juncea.Functional & integrative genomics · 2015Article
- Rapid and reliable identification of tomato fruit weight and locule number loci by QTL-seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Solanum lycopersicum AUXIN RESPONSE FACTOR 9 regulates cell division activity during early tomato fruit development.Journal of experimental botany · 2015Article
- FR database 1.0: a resource focused on fruit development and ripening.Database : the journal of biological databases and curation · 2015Article
- Physalis floridana Cell Number Regulator1 encodes a cell membrane-anchored modulator of cell cycle and negatively controls fruit size.Journal of experimental botany · 2015Article
- Genes involved in floral meristem in tomato exhibit drastically reduced genetic diversity and signature of selection.BMC plant biology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
fw2.2 is one of the few QTLs thus far isolated from plants and the first one known to control fruit size. While it has been established that FW2.2 is a regulator (either directly or indirectly) of cell division, FW2.2 does not share sequence homology to any protein of known function (Frary et al. Science 289:85-88, 2000; Cong et al. Proc Natl Acad Sci USA 99:13606-13611, 2002; Liu et al. Plant Physiol 132:292-299, 2003). Thus, the mechanism by which FW2.2 mediates cell division in developing fruit is currently unknown. In an effort to remedy this situation, a combination of yeast two-hybrid screens, in vitro binding assays and cell bombardment studies were performed. The results provide strong evidence that FW2.2 physically interacts at or near the plasma membrane with the regulatory (beta) subunit of a CKII kinase. CKII kinases are well-studied in both yeast and animals where they form part of cell cycle related signaling pathway. Thus while FW2.2 is a plant-specific protein and regulates cell division in a specialized plant organ (fruit), it appears to participate in a cell-cycle control signal transduction pathway that predates the divergence of single- and multi-cellular organisms. These results thus provide a glimpse into how ancient and conserved regulatory processes can be co-opted in the evolution of novel organs such as fruit.
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