ReviewNeurogenetics2006
Current perspectives on the genetic causes of neural tube defects.
Review in Neurogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 53 citations in OpenAlex.
- Concordant Open Neural Tube Defects in a Monochorionic Twin Pair of a Dichorionic-Triamniotic Triplet Gestation.AJP reports · 2026Article
- Article
- Whole exome sequencing identifies novel predisposing genes in neural tube defects.Molecular genetics & genomic medicine · 2019Article
- Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Roles of planar cell polarity pathways in the development of neural [correction of neutral] tube defects.Journal of biomedical science · 2011Review
- Contribution of VANGL2 mutations to isolated neural tube defects.Clinical genetics · 2011Article
- Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes.Biology direct · 2011Article
- Degree of genetic homozygosity and distribution of AB0 blood types among patients with spina bifida occulta and spina bifida aperta.Archives of medical science : AMS · 2010Article
- Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.Nature cell biology · 2010Article
- Fetal MRI in the evaluation of fetuses referred for sonographically suspected neural tube defects (NTDs): impact on diagnosis and management decision.Neuroradiology · 2009Article
- Planar cell polarity signaling: from fly development to human disease.Annual review of genetics · 2008Review
- Central nervous system birth defects in surgically treated infants in Sarajevo region of Bosnia and Herzegovina.Bosnian journal of basic medical sciences · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural tube defects (NTDs) are a group of severe congenital abnormalities resulting from the failure of neurulation. The pattern of inheritance of these complex defects is multifactorial, making it difficult to identify the underlying causes. Scientific research has rapidly progressed in experimental embryology and molecular genetics to elucidate the basis of neurulation. Crucial mechanisms of neurulation include the planar cell polarity pathway, which is essential for the initiation of neural tube closure, and the sonic hedgehog signaling pathway, which regulates neural plate bending. Genes influencing neurulation have been investigated for their contribution to human neural tube defects, but only genes with well-established role in convergent extension provide an exciting new set of candidate genes. Biochemical factors such as folic acid appear to be the greatest modifiers of NTDs risk in the human population. Consequently, much research has focused on genes of folate-related metabolic pathways. Variants of several such genes have been found to be significantly associated with the risk of neural tube defects in more studies. In this manuscript, we reviewed the current perspectives on the causes of neural tube defects and highlighted that we are still a long way from understanding the etiology of these complex defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.