ArticlePediatric nephrology (Berlin, Germany)2006
Expression profile of nephrin, podocin, and CD2AP in Chinese children with MCNS and IgA nephropathy.
Article in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Slit Diaphragm Molecular Changes in Recurrent FSGS With Antinephrin Autoantibodies.Kidney international reports · 2026Article
- Urinary sediment mRNA as a potent biomarker of IgA nephropathy.BMC nephrology · 2024Article
- Research Progress in Acute Hypertensive Renal Injury by "Journal of translational internal medicine · 2019Review
- Human podocyte injury in the early course of hypertensive renal injury.World journal of clinical cases · 2019Article
- Chronic ethanol ingestion induces glomerular filtration barrier proteins genes expression alteration and increases matrix metalloproteinases activity in the kidney of rats.Interventional medicine & applied science · 2018Article
- Podocyte proteins in congenital and minimal change nephrotic syndrome.Clinical and experimental nephrology · 2015Article
- Extracellular vesicles in the urine: markers and mediators of tissue damage and regeneration.Clinical kidney journal · 2015Article
- Triptolide Attenuates Podocyte Injury by Regulating Expression of miRNA-344b-3p and miRNA-30b-3p in Rats with Adriamycin-Induced Nephropathy.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Heterogeneous genetic alterations in sporadic nephrotic syndrome associate with resistance to immunosuppression.Journal of the American Society of Nephrology : JASN · 2015Article
- Podocin and beta dystroglycan expression to study podocyte-podocyte and basement membrane matrix connections in adult protienuric states.Diagnostic pathology · 2014Article
- Article
- Treatment of tacrolimus or cyclosporine A in children with idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2012Article
- Relevance of VEGF and nephrin expression in glomerular diseases.Journal of signal transduction · 2011Article
- TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes.Journal of the American Society of Nephrology : JASN · 2009Article
- Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis.Kidney & blood pressure research · 2008Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been many exciting advances in our understanding of genetic causes of nephrotic syndrome since 1998 when nephrin was first found. The mRNA expressions of nephrin and CD2AP were studied by quantitative real-time polymerase chain reaction (PCR) in aspirated renal biopsy tissues from 9 subjects with minimal change nephrotic syndrome (MCNS), 6 with primary IgA nephropathy (IgAN), and 15 controls. Protein expression of nephrin, podocin, and CD2AP were analyzed by immunohistochemistry, indirect immunofluorescence, and laser confocal microscope. Compared with controls, the CD2AP mRNA level was significantly downregulated in renal samples from MCNS and IgAN patients (p=0.001 in MCNS, p=0.046 in IgAN), though no significant downregulation was found in the mRNA level of nephrin (p=0.346 in MCNS, p=0.311 in IgAN). The expression levels of protein CD2AP and nephrin were significantly reduced in MCNS and IgAN (MCNS: nephrin, p=0.034, CD2AP, p=0.005; IgAN: nephrin, p=0.021, CD2AP, p=0.025). The podocin staining did not differ significantly between controls and disease groups (p value 0.340 and 0.787, respectively). The results suggest that transcript and translation expression changes of nephrin and CD2AP may have pathogenetic roles in some patients with MCNS and IgAN in Chinese, though no correlation was found in podocin with proteinuria in this study.
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