ArticleEuropean journal of pediatrics2007
Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study.
Article in European journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Balanced crystalloid solutions versus 0.9% saline for treating acute diarrhoea and severe dehydration in children.The Cochrane database of systematic reviews · 2023Pooled it
- Clinical factors predicting rotavirus diarrhea in children: A cross-sectional study from two hospitals.World journal of clinical pediatrics · 2023Article
- Fourteen years' clinical experience and the first million babies protected with human live-attenuated vaccine against rotavirus disease in Italy.Human vaccines & immunotherapeutics · 2021Article
- Rotavirus vaccination for all children or subgroups only? Comment of the European Academy of Paediatrics (EAP) and the European Society for Paediatric Infectious Diseases (ESPID) recommendation group for rotavirus vaccination.European journal of pediatrics · 2020Article
- Article
- Epidemiology and Factors Related to Clinical Severity of Acute Gastroenteritis in Hospitalized Children after the Introduction of Rotavirus Vaccination.Journal of Korean medical science · 2017Article
- In vitro screening for antiviral activity of Turkish plants revealing methanolic extract of Rindera lanata var. lanata active against human rotavirus.BMC complementary and alternative medicine · 2017Article
- Rotavirus gastroenteritis and a rare case accompanying acute pancreatitis.Przeglad gastroenterologiczny · 2017Article
- Changing distribution of age, clinical severity, and genotypes of rotavirus gastroenteritis in hospitalized children after the introduction of vaccination: a single center study in Seoul between 2011 and 2014.BMC infectious diseases · 2016Article
- Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India.Virusdisease · 2016Article
- Chloride secretion induced by rotavirus is oxidative stress-dependent and inhibited by Saccharomyces boulardii in human enterocytes.PloS one · 2014Article
- Management strategies in the treatment of neonatal and pediatric gastroenteritis.Infection and drug resistance · 2013Review
- Acute viral gastroenteritis in children hospitalized in Iksan, Korea during December 2010-June 2011.Korean journal of pediatrics · 2013Article
- Prevalence and factors associated with rotavirus infection among children admitted with acute diarrhea in Uganda.BMC pediatrics · 2010Article
- Article
- A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis.European journal of pediatrics · 2009Article
- Rotaviruses: from pathogenesis to vaccination.Gastroenterology · 2009Review
- The impact of rotavirus gastroenteritis on the family.BMC pediatrics · 2009Article
- Article
- Pentavalent human-bovine (WC3) reassortant rotavirus vaccine in special populations: a review of data from the Rotavirus Efficacy and Safety Trial.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe severity of childhood gastroenteritis is generally believed to be age-related rather than aetiology-related. Rotavirus-induced gastroenteritis is more severe than gastroenteritis caused by other enteric pathogens and is also age-related. We thus addressed the question of whether the increased severity of rotavirus-induced gastroenteritis is related to age or to features intrinsic to the agent. STUDY
designIn this multicentre, hospital-based, prospective survey, we evaluated the severity of diarrhoea in rotavirus-positive and rotavirus-negative children up to 4 years of age. Severity was assessed with a score in four groups of age-matched children.
resultsRotavirus was detected in 381 of 911 children. Disease severity was evaluated in 589 cases for which clinical data were complete. The rotavirus-positive and rotavirus-negative groups differed with regards to diarrhoea duration, hospital stay, degree of dehydration and the number of episodes of vomiting. Gastroenteritis was more severe in rotavirus-positive than in rotavirus-negative children. In contrast, none of the main severity parameters differed in the four age groups, irrespective of the presence of rotavirus.
conclusionsThese data provide the evidence that aetiology and not age determines diarrhoeal severity. The demonstration that diarrhoea was more severe in rotavirus-positive children supports the need for a rotavirus vaccine and for studies that address the duration of vaccine protection.
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