ArticleImmunogenetics2006
Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 79 citations in OpenAlex.
- Distinct distribution and responses of IgMFrontiers in immunology · 2024Article
- Immunoglobulin genes, reproductive isolation and vertebrate speciation.Immunology and cell biology · 2022Article
- Mystifying Molecular Structure, Expression and Repertoire Diversity of IgM Heavy Chain Genes (Frontiers in immunology · 2022Article
- Immunoglobulins in teleosts.Immunogenetics · 2021Review
- Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes.Proceedings. Biological sciences · 2020Article
- Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish.Frontiers in immunology · 2020Review
- Fish Immunoglobulins.Biology · 2016Review
- B cells and their role in the teleost gut.Developmental and comparative immunology · 2016Review
- Identification and characterization of TCRγ and TCRδ chains in channel catfish, Ictalurus punctatus.Immunogenetics · 2014Article
- The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens.Fish & shellfish immunology · 2013Review
- Teleost skin, an ancient mucosal surface that elicits gut-like immune responses.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The astonishing diversity of Ig classes and B cell repertoires in teleost fish.Frontiers in immunology · 2013Article
- Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates.Frontiers in immunology · 2012Article
- Mucosal immunoglobulins and B cells of teleost fish.Developmental and comparative immunology · 2011Review
- Recent findings on the structure and function of teleost IgT.Fish & shellfish immunology · 2011Review
- Immunoglobulin heavy chains in medaka (Oryzias latipes).BMC evolutionary biology · 2011Article
- The zebrafish IgH locus contains multiple transcriptional regulatory regions.Developmental and comparative immunology · 2011Article
- Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish.Immunology · 2011Article
- Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar.BMC genomics · 2010Article
- Channel catfish soluble FcmuR binds conserved linear epitopes present on Cmu3 and Cmu4.Molecular immunology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The catfish IGH locus is large ( approximately 1 Mb) and complex, having undergone multiple internal duplications and transpositions. To define the structure of the locus that contains the single expressed IGHM gene, two overlapping bacterial-artificial-chromosome (BAC) clones spanning the most 3' end of the channel catfish immunoglobulin heavy (IGH) chain locus have been completely sequenced. The analyses created a contig of 257,153 bp containing 55 VH, 6 D, 12 JH genes and the IGH constant region genes encoding the functional secreted and membrane forms of IgM and the membrane form of IgD. This analysis revealed three major features. First, no C-region genes were found aside from the previously described IGHM1 and IGHD1, with the latter gene being the most 3' C-region gene of the catfish IGH locus. There was no evidence in the region sequenced for genes that could encode an Ig class similar to the IgZ/IgT described in zebrafish, trout and pufferfish. Second, there are a high number of VH pseudogenes, 28 out of 55 (51%). In contrast, the entire zebrafish IGH locus has 40 functional VH genes and eight pseudogenes (17%). Third, an internal duplication of a 52.4-kb block of VH genes has occurred. These observations suggest that the IGH locus of teleost fish varies significantly from species to species in the diversity of C-region genes as well as the numbers of genes encoding V regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.