ArticleBritish journal of pharmacology2006
Greater antiarrhythmic activity of acute 17beta-estradiol in female than male anaesthetized rats: correlation with Ca2+ channel blockade.
Article in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The association between skipping breakfast and cardiovascular disease: a meta analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Sudden Death in Men Versus Women with Heart Failure.Current heart failure reports · 2023Review
- The Effects of Different Hormones on Supraventricular and Ventricular Premature Contractions in Healthy Premenopausal Women.Medicina (Kaunas, Lithuania) · 2021Article
- Arrhythmia in Cardiomyopathy: Sex and Gender Differences.Current heart failure reports · 2021Review
- Integrated Pharmacogenetics Analysis of the Three Fangjis Decoctions for Treating Arrhythmias Based on Molecular Network Patterns.Frontiers in cardiovascular medicine · 2021Article
- The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy.Biology of sex differences · 2017Review
- Sex differences and effects of oestrogen in rat gastric mucosal defence.World journal of gastroenterology · 2017Article
- Efficacy of female rat models in translational cardiovascular aging research.Journal of aging research · 2014Review
- Effects of short-term administration of estradiol on reperfusion arrhythmias in rats of different ages.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Mechanism of estradiol-induced block of voltage-gated K+ currents in rat medial preoptic neurons.PloS one · 2011Article
- Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study.PLoS computational biology · 2010Article
- Sex hormones and arrhythmia in myocardial ischemia.British journal of pharmacology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeFemale sex hormones may protect pre-menopausal women from sudden cardiac death. We therefore investigated the effects of the main female sex hormone, 17beta-estradiol, on ischaemia-induced cardiac arrhythmias and on the L-type Ca2+ current (ICaL). EXPERIMENTAL APPROACH: In vivo experiments were performed in pentobarbital-anaesthetized rats subjected to acute coronary artery occlusion. ICaL was measured by the whole-cell patch-clamp technique, in rat isolated ventricular myocytes. KEY
resultsAcute intravenous administration of 17beta-estradiol as a bolus dose followed by a continuous infusion, commencing 10 min before coronary artery occlusion, had dose-dependent antiarrhythmic activity. In female rats 300 ng kg(-1) + 30 ng kg(-1) min(-1) 17beta-estradiol significantly reduced the number of ventricular premature beats (VPBs) and the incidence of ventricular fibrillation (VF). A ten fold higher dose of 17beta-estradiol was required to cause similar effects in male rats. In vitro 17beta-estradiol reduced peak ICaL in a concentration-dependent manner. The EC50 was ten-fold higher in male myocytes (0.66 microM) than in females (0.06 microM). CONCLUSIONS AND IMPLICATIONS: These results indicate that 17beta-estradiol has marked dose-dependent antiarrhythmic activity that is greater in female rats than in males. A similar differential potency in blocking ICaL in myocytes from female and male rats can account for this effect. This provides an explanation for the antiarrhythmic activity of 17beta-estradiol and gender-selective protection against sudden cardiac death.
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