Evidence map›Paper›PMID 16940978›Full record

ArticleBritish journal of cancer2006

Prognostic factors in metastatic renal cell carcinoma: metastasectomy as independent prognostic variable.

U M Vogl, H Zehetgruber, M Dominkus, M Hejna, C C Zielinski, A Haitel, M Schmidinger

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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  15. Association of decreased mean platelet volume with renal cell carcinoma.International journal of clinical oncology · 2017
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  19. A unique presentation of a renal clear cell carcinoma with atypical metastases.International journal of surgery case reports · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

U M VoglDepartment of Medicine I, Clinical Division of Oncology, University Hospital, Waehringer Guertel 18-20, Vienna A-1090, Austria. ursula.vogl@meduniwien.ac.at
H Zehetgruber
M Dominkus
M Hejna
C C Zielinski
A Haitel
M Schmidinger
Vienna General Hospital · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prognostic and predictive factors in patients with metastatic renal cell carcinoma (MRCC) have been evaluated from untreated patients or patients on several different treatment approaches. The aim of this analysis was to define prognostic and predictive factors in patients treated uniformly with a low-dose outpatient cytokine combination. The relationship between patient-, tumour-, and treatment-related factors was analysed in 99 patients with MRCC. These features were first examined in univariate analyses, then a stepwise modelling approach based on Cox regression was used to form a multivariate model. Nuclear grade, metastasectomy--even incomplete--C-reactive protein and lactate dehydrogenase were identified as independent prognostic factors for survival. Patients assigned to three different risk groups had statistically significant survival differences (30, 22 and 6 months, respectively). A total of 43.4% had undergone metastasectomy, mostly incomplete. Risk group affiliation was correlated with response to treatment. Our findings strongly suggest the consideration of metastasectomy in the management of patients with metastatic renal cell cancer undergoing either immunotherapy or targeted treatment.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Renal CellC-Reactive ProteinFemaleHumansImmunotherapyKidney NeoplasmsL-Lactate DehydrogenaseMaleMiddle AgedMultivariate AnalysisNeoplasm MetastasisPredictive Value of TestsBiomarkers, TumorC-Reactive ProteinL-Lactate Dehydrogenase

Identifiers

PMID16940978
PMCPMC2360513
OpenAlexW2063903287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.