ArticleJournal of perinatology : official journal of the California Perinatal Association2006
Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- The efficacy and safety of fluconazole in preventing invasive fungal infection in very low birth weight infants: a systematic review and meta-analysis.Italian journal of pediatrics · 2023Pooled it
- Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants.The Cochrane database of systematic reviews · 2015Pooled it
- Safety of fluconazole in paediatrics: a systematic review.European journal of clinical pharmacology · 2013Pooled it
- Oral nystatin prophylaxis to prevent systemic fungal infection in very low birth weight preterm infants: a randomized controlled trial.BMC pediatrics · 2020Trial
- Population Pharmacokinetic Study of Prophylactic Fluconazole in Preterm Infants for Prevention of Invasive Candidiasis.Antimicrobial agents and chemotherapy · 2019Trial
- Invasive Candida Infections in Neonatal Intensive Care Units: Risk Factors and New Insights in Prevention.Pathogens (Basel, Switzerland) · 2024Review
- Infection prevention for extremely low birth weight infants in the NICU.Seminars in fetal & neonatal medicine · 2022Review
- Fluconazole prophylaxis against invasive candidiasis in very low and extremely low birth weight preterm neonates: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2021Article
- Review
- Does fluconazole prophylaxis reduce death or invasive candida infection in extremely preterm infants?Acta paediatrica (Oslo, Norway : 1992) · 2017Article
- Usefulness of direct fluorescent in buffy coat in the diagnosis of Candida sepsis in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Efficacy and safety of fluconazole prophylaxis in extremely low birth weight infants: multicenter pre-post cohort study.BMC pediatrics · 2016Observational
- Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Single Center Experience.Pediatric gastroenterology, hepatology & nutrition · 2016Article
- Article
- Advances in the treatment of invasive neonatal candidiasis.Expert opinion on pharmacotherapy · 2015Review
- Triazole use in the nursery: fluconazole, voriconazole, posaconazole, and ravuconazole.Current drug metabolism · 2013Review
- Treatment and prophylaxis of invasive candidiasis.Seminars in perinatology · 2012Review
- European survey on the use of prophylactic fluconazole in neonatal intensive care units.European journal of pediatrics · 2012Article
- Impact of 'targeted' fluconazole prophylaxis for preterm neonates: efficacy of a highly selective approach?Journal of perinatology : official journal of the California Perinatal Association · 2012Article
- Fluconazole pharmacokinetics and safety in premature infants.Current medicinal chemistry · 2012Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtremely low birth weight (ELBW) infants are at increased risk for invasive candidiasis and associated morbidity and mortality. The use of fluconazole prophylaxis in this population has raised a benefit versus risk concern among clinicians.
objectivesTo evaluate the effectiveness and safety of fluconazole prophylaxis in ELBW infants. STUDY
designELBW infants (BW<or=1,000 g) born during the pre-prophylaxis era (PPE, January 1998-February 2002) were compared with prophylaxis era (PE, March 2002-September 2005). Infants born during PE received fluconazole prophylaxis for 6 weeks, as long as they had intravenous access. Demographic and clinical data were collected. The two groups were compared for baseline demographics, risk factors for candidiasis, the incidence of invasive candidiasis, liver enzymes, alkaline phosphatase, and bilirubin (total and direct).
resultsNine out of 137 infants (6.6%) developed invasive candidiasis during PPE compared to none of 140 (0%) during PE (P=0.006). During PE, 60/140 (42.9%) infants developed conjugated hyperbilirubinemia compared to 12/137 (8.8%) during PPE (P<0.001).
conclusionAlthough a fluconazole prophylaxis regimen for ELBW infants was effective in preventing invasive candidiasis, an increase in the incidence of conjugated hyperbilirubinemia was observed. Further studies are needed to evaluate the safety of fluconazole prophylaxis in this population.
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