ArticleThe American journal of pathology1990
Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 134 citations in OpenAlex.
- Durable response but prolonged cytopenia after cladribine treatment in relapsed patients with indolent non-Hodgkin's lymphomas: results of a Japanese phase II study.International journal of hematology · 2004Trial
- Intratumoral T-cell composition predicts epcoritamab-based treatment efficacy in B-cell non-Hodgkin lymphomas.medRxiv : the preprint server for health sciences · 2024Article
- Assessment of anti-CD20 antibody pre-treatment for augmentation of CAR-T cell therapy in SIV-infected rhesus macaques.Frontiers in immunology · 2023Article
- Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates.Frontiers in immunology · 2019Article
- Brain stereotactic biopsy flow cytometry for central nervous system lymphoma characterization: advantages and pitfalls.Journal of experimental & clinical cancer research : CR · 2016Article
- Genetic and Epigenetic Modulation of CD20 Expression in B-Cell Malignancies: Molecular Mechanisms and Significance to Rituximab Resistance.Journal of clinical and experimental hematopathology : JCEH · 2016Article
- Site-specific analysis of inflammatory markers in discoid lupus erythematosus skin.TheScientificWorldJournal · 2014Article
- Myofibroblast activation in colorectal cancer lymph node metastases.British journal of cancer · 2013Article
- Comparison of CD20 expression in B-cell lymphoma between newly diagnosed, untreated cases and those after rituximab treatment.Cancer science · 2012Article
- The identification of irreversible rituximab-resistant lymphoma caused by CD20 gene mutations.Blood cancer journal · 2011Article
- Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival.Blood · 2009Article
- CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure.Haematologica · 2009Article
- Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy.International journal of hematology · 2007Article
- Development, maturation and subsequent activation of follicular dendritic cells (FDC): immunohistochemical observation of human fetal and adult lymph nodes.Histochemistry and cell biology · 2006Article
- Thymus development in Macaca fascicularis (Cynomolgus monkey): an approach for toxicology and embryology.Journal of molecular histology · 2006Article
- Growth pattern and distribution of follicular dendritic cells in mantle cell lymphoma: a clinicopathological study of 96 patients.Virchows Archiv : an international journal of pathology · 2006Article
- The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?The American journal of pathology · 2001Article
- Reconstitution of the CD45RO(+) and CD20(+) lymphoid marrow population following allogeneic bone marrow transplantation for Ph(+) CML.Bone marrow transplantation · 2001Article
- Article
- Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region.The American journal of pathology · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoclonal antibody L26 is a highly selective marker of B cells and B-cell neoplasms in paraffin-embedded tissues, but it suffers from the drawback that the target molecule has not been identified. In this paper we provide evidence by two independent techniques that antibody L26 recognizes an intracellular epitope on the CD20 antigen (a pan B-cell marker). When this antigen was redistributed on the surface of unfixed viable B cells by incubation with monoclonal anti-CD20 followed by anti-mouse Ig, the diffuse cytoplasmic staining of L26 was abolished and replaced by coincident dotlike labeling for antibody L26 and the CD20 antigen. None of the other antibodies tested (covering 10 different B-cell-associated antigens) had this effect on the L26 staining pattern. Furthermore, COS-1 cells transfected with cDNA encoding the CD20 molecule gave positive staining with antibody L26 and with two other CD20 reagents, but not with antibodies to other pan B-cell markers (eg, CD19 and CD22).
Indexed as
Identifiers
1694056PMC1877587W169055161What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.