ArticleRNA (New York, N.Y.)2006
Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae.
Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 99 citations in OpenAlex.
- Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.bioRxiv : the preprint server for biology · 2026Article
- Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress.eLife · 2024Article
- Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress.bioRxiv : the preprint server for biology · 2024Article
- Single-molecule imaging reveals translation-dependent destabilization of mRNAs.Molecular cell · 2023Article
- Post-transcriptional regulation during stress.FEMS yeast research · 2022Review
- Determinants of the temperature adaptation of mRNA degradation.Nucleic acids research · 2022Article
- Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors.Molecular cell · 2020Article
- A Forward Genetic Approach to Mapping aG3 (Bethesda, Md.) · 2020Article
- The Dynamics of Cytoplasmic mRNA Metabolism.Molecular cell · 2020Article
- mRNA with Mammalian Codon Bias Accumulates in Yeast Mutants with Constitutive Stress Granules.International journal of molecular sciences · 2020Article
- Absolute Quantification of Noncoding RNA by Microscale Thermophoresis.Angewandte Chemie (International ed. in English) · 2019Article
- Stress-induced mRNP granules: Form and function of processing bodies and stress granules.Wiley interdisciplinary reviews. RNA · 2019Review
- An annual cycle of gene regulation in the red-legged salamander mental gland: from hypertrophy to expression of rapidly evolving pheromones.BMC developmental biology · 2019Article
- Translational regulation in response to stress in Saccharomyces cerevisiae.Yeast (Chichester, England) · 2019Review
- RNA Degradation in Neurodegenerative Disease.Advances in neurobiology · 2018Review
- Short poly(A) tails are a conserved feature of highly expressed genes.Nature structural & molecular biology · 2017Article
- Regulation of mRNA decay in plant responses to salt and osmotic stress.Cellular and molecular life sciences : CMLS · 2017Review
- An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress.Scientific reports · 2017Article
- Coupling of Ribostasis and Proteostasis: Hsp70 Proteins in mRNA Metabolism.Trends in biochemical sciences · 2015Review
- Large-Scale Analysis of Kinase Signaling in Yeast Pseudohyphal Development Identifies Regulation of Ribonucleoprotein Granules.PLoS genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Post-transcriptional control mechanisms play an important role in regulating gene expression during cellular responses to stress. For example, many stresses inhibit translation, and at least some stresses inhibit mRNA turnover in yeast and mammalian cells. We show that hyperosmolarity, heat shock, and glucose deprivation stabilize multiple mRNAs in yeast, primarily through inhibition of deadenylation. Although these stresses inhibit translation and promote the movement of mRNAs into P-bodies, we also observed inhibition of deadenylation in cycloheximide-treated cells as well as in a mutant strain where translation initiation is impaired. This argues that inhibition of poly(A)-shortening is independent of the translational state of the mRNAs and can occur when mRNAs are localized in polysomes or are not engaged in translation. Analysis of pan2Delta or ccr4Delta strains indicates that stress inhibits the function of both the Ccr4p/Pop2p/Notp and the Pan2p/Pan3p deadenylases. We suggest that under stress, simultaneous repression of translation and deadenylation allows cells to selectively translate mRNAs specific to the stress response, while retaining the majority of the cytoplasmic pool of mRNAs for later reuse and recovery from stress. Moreover, because various cellular stresses also inhibit deadenylation in mammalian cells, this mechanism is likely to be a conserved aspect of the stress response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.