ArticleJournal of virology2006
Transcriptional profiling reveals a possible role for the timing of the inflammatory response in determining susceptibility to a viral infection.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
- Virus and host-associated variations in the interaction of low-pathogenic avian influenza viruses with the epithelial target tissue of the chicken reproductive tract.Veterinary research · 2026Article
- Comprehensive transcriptome profiling of the chicken bursa infected with the novel variant infectious bursal disease virus.Poultry science · 2026Article
- Effects of immunosuppression on tracheal mucosal responses after infection withFrontiers in immunology · 2026Article
- Enhancing MyD88 oligomerization is one important mechanism by which IBDV VP2 induces inflammatory response.PLoS pathogens · 2025Article
- The long noncoding RNA loc107053557 acts as a gga-miR-3530-5p sponge to suppress the replication of vvIBDV through regulating STAT1 expression.Virulence · 2024Article
- Genome-wide identification of chicken bursae of Fabricius miRNAs in response to very virulent infectious bursal disease virus.Archives of virology · 2022Article
- Chicken Mesenchymal Stem Cells and Their Applications: A Mini Review.Animals : an open access journal from MDPI · 2021Review
- Functional prediction of de novo uni-genes from chicken transcriptomic data following infectious bursal disease virus at 3-days post-infection.BMC genomics · 2021Article
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- Current Findings on Gut Microbiota Mediated Immune Modulation against Viral Diseases in Chicken.Viruses · 2019Review
- Effect of Soybean Isoflavones on Growth Performance, Immune Function, and Viral Protein 5 mRNA Expression in Broiler Chickens Challenged with Infectious Bursal Disease Virus.Animals : an open access journal from MDPI · 2019Article
- Deciphering desirable immune responses from disease models with resistant and susceptible chickens.Poultry science · 2019Review
- Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses.PloS one · 2019Article
- Infectious bursal disease virus in chickens: prevalence, impact, and management strategies.Veterinary medicine (Auckland, N.Z.) · 2019Article
- Macrophage Migration Inhibitory Factor Triggers Inflammatory Responses During Very Virulent Infectious Bursal Disease Virus Infection.Frontiers in microbiology · 2019Article
- An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis.Journal of visualized experiments : JoVE · 2018Article
- Transcription profiles of the responses of chicken bursae of Fabricius to IBDV in different timing phases.Virology journal · 2017Article
- Infectious bursal disease virus in poultry: current status and future prospects.Veterinary medicine (Auckland, N.Z.) · 2016Review
- Analysis of the early immune response to infection by infectious bursal disease virus in chickens differing in their resistance to the disease.Journal of virology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a novel cDNA microarray prepared from sources of actively responding immune system cells, we have investigated the changes in gene expression in the target tissue during the early stages of infection of neonatal chickens with infectious bursal disease virus. Infections of two lines of chickens previously documented as genetically resistant and sensitive to infection were compared in order to ascertain early differences in the response to infection that might provide clues to the mechanism of differential genetic resistance. In addition to major changes that could be explained by previously described changes in infected tissue, some differences in gene expression on infection, and differences between the two chicken lines, were observed that led to a model for resistance in which a more rapid inflammatory response and more-extensive p53-related induction of apoptosis in the target B cells might limit viral replication and consequent pathology. Ironically, the effect in the asymptomatic neonatal infection is that more-severe B-cell depletion is seen in the more genetically resistant chicken. Changes of expression of many chicken genes of unknown function, indicating possible roles in the response to infection, may aid in the functional annotation of these genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.