ArticleJournal of virology2006
Phylogenetic analysis of polyomavirus BK sequences.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Article
- BK Polyomavirus Subtypes IVc-1 and Ib-1 in Vietnamese Renal Transplant Recipients.Microbiology resource announcements · 2021Article
- Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization.PLoS pathogens · 2021Article
- Persistent BK Polyomavirus Viruria is Associated with Accumulation of VP1 Mutations and Neutralization Escape.Viruses · 2020Article
- BK polyomavirus diversity-Why viral variation matters.Reviews in medical virology · 2020Review
- Deciphering the Prognostic and Predictive Value of Urinary CXCL10 in Kidney Recipients With BK Virus Reactivation.Frontiers in immunology · 2020Observational
- Complete Genome Sequence of Original Material Used To Derive the WHO International Standard for Human Polyomavirus BK DNA.Microbiology resource announcements · 2019Article
- Polyoma virus nephropathy in kidney transplantation.World journal of transplantation · 2017Review
- BK polyoma virus infection and renal disease in non-renal solid organ transplantation.Clinical kidney journal · 2016Review
- Comparative Evaluation of Three Nucleic Acid-Based Assays for BK Virus Quantification.Journal of clinical microbiology · 2015Article
- The oncogenic potential of BK-polyomavirus is linked to viral integration into the human genome.The Journal of pathology · 2015Article
- Phylogenetic reconstruction and polymorphism analysis of BK virus VP2 gene isolated from renal transplant recipients in China.Experimental and therapeutic medicine · 2015Article
- Contamination of SVG p12 cells with BK polyomavirus occurred after deposit in the American Type Culture Collection.Journal of virology · 2014Article
- The human fetal glial cell line SVG p12 contains infectious BK polyomavirus.Journal of virology · 2014Article
- BK polyomavirus genotypes represent distinct serotypes with distinct entry tropism.Journal of virology · 2013Article
- Immunity to Polyomavirus BK Infection: Immune Monitoring to Regulate the Balance between Risk of BKV Nephropathy and Induction of Alloimmunity.Clinical & developmental immunology · 2013Review
- BK polyomavirus: emerging pathogen.Microbes and infection · 2012Review
- VP-1 quasispecies in human infection with polyomavirus BK.Journal of medical virology · 2012Article
- Impact of genomic sequence variability on quantitative PCR assays for diagnosis of polyomavirus BK infection.Journal of clinical microbiology · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Polyomavirus BK (BKV) has emerged as an important pathogen in kidney transplant patients. Existing taxonomic classifications of BKV come from conventional DNA sequence alignments based on limited data derived from the VP1 gene. We have used a phylogenetic whole-genome approach to examine the pattern of diversity and evolutionary relationships between 45 BKV strains isolated from multiple clinical settings. This analysis supports the classification of BKV into six genotypes, of which types V and VI have not been previously recognized. BKV strains hitherto classified as type I are, in fact, quite heterogeneous, and several cluster with our newly defined genotypes V and VI. The sequence information needed for assigning genotypes can be captured by VP1, VP2, VP3, or large T-gene sequencing. The most polymorphic coding region in the viral genome is VP1, but significant variation is also present in the large T-antigen gene, wherein polymorphisms are found in 11.39% of all nucleotide sites, 46.22% of which are cluster specific. Type-specific amino acid changes within the VP1 region are predicted to map to the BC and DE loops. The number of taxonomically informative amino acid changes in the large T antigen exceeds even that of the VP1 region. Viral strains isolated from healthy subjects and from patients with human immunodeficiency virus infection, Wiskott-Aldrich syndrome, and vasculopathy with capillary leak syndrome formed distinct subclusters. However, within the kidney transplant population, BKV strains derived from patients with asymptomatic viruria did not show complete separation from strains associated with allograft nephropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.