ArticleBlood2007
T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 70 citations in OpenAlex.
- Transcriptional Regulation of Early T-Lymphocyte Development in Thymus.Frontiers in immunology · 2022Review
- Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment.Biophysical journal · 2021Review
- A rare description of pure partial trisomy of 16q12.2q24.3 and review of the literature.American journal of medical genetics. Part A · 2021Article
- Article
- A lineage-specific requirement for YY1 Polycomb Group protein function in early T cell development.Development (Cambridge, England) · 2021Article
- How transcription factors drive choice of the T cell fate.Nature reviews. Immunology · 2021Review
- Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Programming for T-lymphocyte fates: modularity and mechanisms.Genes & development · 2019Review
- Cutting Edge: Core Binding Factor β Is Required for Group 2 Innate Lymphoid Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.Immunity · 2018Article
- Development and differentiation of early innate lymphoid progenitors.The Journal of experimental medicine · 2018Article
- Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia.Blood advances · 2017Article
- The RUNX complex: reaching beyond haematopoiesis into immunity.Immunology · 2015Review
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
- Transcriptional control of early T and B cell developmental choices.Annual review of immunology · 2014Review
- Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.Molecular cell · 2012Article
- From murine to human nude/SCID: the thymus, T-cell development and the missing link.Clinical & developmental immunology · 2012Review
- Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.Cell stem cell · 2011Article
- miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies.The Journal of biological chemistry · 2011Article
- Factors and networks that underpin early hematopoiesis.Seminars in immunology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The family of core-binding factors includes the DNA-binding subunits Runx1-3 and their common non-DNA-binding partner CBFbeta. We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series. Reducing CBFbeta levels by 3- or 6-fold caused abnormalities in bone development, megakaryocytes, granulocytes, and T cells. T-cell development was very sensitive to an incremental reduction of CBFbeta levels: mature thymocytes were decreased in number upon a 3-fold reduction in CBFbeta levels, and were virtually absent when CBFbeta levels were 6-fold lower. Partially penetrant consecutive differentiation blocks were found among early T-lineage progenitors within the CD4- CD8- double-negative 1 and downstream double-negative 2 thymocyte subsets. Our data define a critical CBFbeta threshold for normal T-cell development, and situate an essential role for core-binding factors during the earliest stages of T-cell development.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.