Trial reportAntimicrobial agents and chemotherapy2006
Comparative efficacies of amoxicillin, clindamycin, and moxifloxacin in prevention of bacteremia following dental extractions.
Trial report in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A New Antibiotic Prophylaxis Regimen to Prevent Bacteremia Following Dental Procedures
An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following
Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery
An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- The Role of Antibiotic Use in Third Molar Tooth Extractions: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials.Clinical oral investigations · 2022Pooled it
- A Systematic Review and Meta-Analysis Evaluating Antibiotic Prophylaxis in Dental Implants and Extraction Procedures.Medicina (Kaunas, Lithuania) · 2018Pooled it
- Effects of clindamycin and amoxycillin as prophylaxis against early implant failure: double-blinded randomized clinical trial.Clinical oral investigations · 2024Trial
- A comparative study of amoxicillin, clindamycin and chlorhexidine in the prevention of post-extraction bacteraemia.Cardiovascular journal of Africa · 2012Trial
- Microbiological analysis of a prospective, randomized, double-blind trial comparing moxifloxacin and clindamycin in the treatment of odontogenic infiltrates and abscesses.Antimicrobial agents and chemotherapy · 2012Trial
- Comparative efficacy and safety of moxifloxacin and clindamycin in the treatment of odontogenic abscesses and inflammatory infiltrates: a phase II, double-blind, randomized trial.Antimicrobial agents and chemotherapy · 2011Trial
- Synthesis of an Enzyme-Triggered Chitosan-Based Drug Delivery System for Peri-Implantitis Prevention.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Mapping Review of the Correlations Between Periodontitis, Dental Caries, and Endocarditis.Dentistry journal · 2025Review
- Healing of Extensive Through-and-Through Periradicular Lesion Using Apicoectomy Without Bone Grafting: A Case Report With 3-Year Recall.Case reports in dentistry · 2025Article
- Alternatives to β-Lactams as Agents for the Management of Dentoalveolar Abscess.Current topics in medicinal chemistry · 2024Review
- Antibiotic resistance of the bacterial spectrum of deep space head and neck infections in oral and maxillofacial surgery - a retrospective study.Clinical oral investigations · 2023Article
- Impact of the COVID-19 Pandemic on Antibiotic Prescribing by Dentists in Galicia, Spain: A Quasi-Experimental Approach.Antibiotics (Basel, Switzerland) · 2022Article
- Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis.International journal of nanomedicine · 2022Article
- Evaluation of the Effect of Preoperative Amoxicillin on Bacteremia Associated with Exodontia in Periodontal and Periapical Pathology.Journal of pharmacy & bioallied sciences · 2021Article
- Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications.Bone · 2021Article
- Antibiotic Therapy in Dentistry.International journal of dentistry · 2021Review
- Comparison of sensitivity of bacteria isolated in odontogenic infections to ceftriaxone and amoxicillin-clavulanate.African health sciences · 2019Article
- Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient Basis.BioMed research international · 2019Article
- The efficiency of topical anesthetics as antimicrobial agents: A review of use in dentistry.Journal of dental anesthesia and pain medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the efficacies of oral prophylactic treatment with amoxicillin (AMX), clindamycin (CLI), and moxifloxacin (MXF) in the prevention of bacteremia following dental extractions (BDE). Two hundred twenty-one adults who required dental extractions under general anesthesia were randomly assigned to a control group, an AMX group, a CLI group, and an MXF group (the individuals in the drug treatment groups received 2 g, 600 mg, and 400 mg, respectively, 1 to 2 h before anesthesia induction). Venous blood samples were collected from each patient at the baseline and 30 s, 15 min, and 1 h after the dental extractions. The samples were inoculated into BACTEC Plus aerobic and anaerobic blood culture bottles and were processed in a BACTEC 9240 instrument. Subculture and the further identification of the isolated bacteria were performed by conventional microbiological techniques. The prevalences of BDE in the control group, AMX group, CLI group, and MXF group were 96, 46, 85, and 57%, respectively, at 30 s; 64, 11, 70, and 24%, respectively, at 15 min; and 20, 4, 22, and 7%, respectively, at 1 h. Streptococcus spp. were the most frequently identified bacteria in all groups (44 to 68%), with the lowest percentage being detected in the AMX group (44%). AMX and MXF prophylaxis showed high efficacies in reducing the prevalence and duration of BDE, but CLI prophylaxis was noneffective. As a consequence, MXF prophylaxis is a promising antibiotic alternative for the prevention of BDE when beta-lactams are not indicated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.