ArticleAntimicrobial agents and chemotherapy2006
Detection of extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 131 citations in OpenAlex.
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- Antibiotic Resistance in Pseudomonas.Advances in experimental medicine and biology · 2022Article
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- Occurrence, antimicrobial susceptibility, and pathogenic factors ofVeterinary world · 2021Article
- The Building Blocks of Antimicrobial Resistance inFrontiers in cellular and infection microbiology · 2021Review
- Prevalence and Phenotypic and Genotypic Resistance Mechanisms of Multidrug-ResistantJournal of environmental and public health · 2021Article
- Genomic Epidemiology ofFrontiers in veterinary science · 2020Article
- Analysis of bacteriological pollution and the detection of antibiotic resistance genes of prevailing bacteria emanating from pig farm seepage.MicrobiologyOpen · 2019Article
- Characterization of cefotaxime resistant Escherichia coli isolated from broiler farms in Ecuador.PloS one · 2019Article
- Co-production of AmpC and extended spectrum beta-lactamases in cephalosporin-resistant Acinetobacter baumannii in Egypt.World journal of microbiology & biotechnology · 2018Article
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- Draft Genome Sequence ofGenome announcements · 2018Article
- Genomic Characterization of Extended-Spectrum Cephalosporin-ResistantFrontiers in microbiology · 2018Article
- Superbugs in the supermarket? Assessing the rate of contamination with third-generation cephalosporin-resistant gram-negative bacteria in fresh Australian pork and chicken.Antimicrobial resistance and infection control · 2018Article
- Virulence genome analysis ofGenomics data · 2017Article
- Distribution ofJournal of preventive medicine and hygiene · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the occurrence of extended-spectrum beta-lactamases (ESBLs) in Pseudomonas aeruginosa being increasingly reported worldwide, there is a need for a reliable test to detect ESBLs in clinical isolates of P. aeruginosa. In our study, a total of 75 clinical isolates of P. aeruginosa were studied. Nitrocefin tests were performed to detect the beta-lactamase enzyme; isoelectric focusing electrophoresis, PCR, and PCR product sequencing were designed to further characterize the contained ESBLs. Various ESBL-screening methods were designed to compare the reliabilities of detecting ESBLs in clinical isolates of P. aeruginosa whose beta-lactamases were well characterized. Thirty-four of 36 multidrug-resistant P. aeruginosa clinical isolates were positive for ESBLs. bla(VEB-3) was the most prevalent ESBL gene in P. aeruginosa in our study. Among the total of 34 isolates that were considered ESBL producers, 20 strains were positive using conventional combined disk tests and 10 strains were positive using a conventional double-disk synergy test (DDST) with amoxicillin-clavulanate, expanded-spectrum cephalosporins, aztreonam, and cefepime. Modifications of the combined disk test and DDST, which consisted of shorter distances between disks (20 mm instead of 30 mm) and the use of three different plates that contained cloxacillin (200 microg/ml) alone, Phe-Arg beta-naphthylamide dihydrochloride (MC-207,110; 20 microg/ml) alone, and both cloxacillin (200 microg/ml) and MC-207,110 (20 microg/ml) increased the sensitivity of the tests to 78.8%, 91.18%, 85.29%, and 97.06%.
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