ArticleAntimicrobial agents and chemotherapy2006
Evolution and global dissemination of macrolide-resistant group A streptococci.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Novel perspectives on the role of the human microbiota in regenerative medicine and surgery.Biomedical reports · 2016Article
- Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing.Annals of laboratory medicine · 2016Article
- Molecular Basis for Erythromycin Resistance in Group A Streptococcus Isolated From Skin and Soft Tissue Infections.Journal of clinical and diagnostic research : JCDR · 2015Article
- Molecular epidemiology and genomics of group A Streptococcus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- Article
- Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development.Clinical and vaccine immunology : CVI · 2014Article
- Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance.FEMS microbiology reviews · 2011Review
- Emergence of erythromycin- and clindamycin-resistant Streptococcus pyogenes emm 90 strains in Hawaii.Journal of clinical microbiology · 2011Article
- Lysogenic transfer of mef(A) and tet(O) genes carried by Phim46.1 among group A streptococci.Antimicrobial agents and chemotherapy · 2010Article
- A decade of molecular pathogenomic analysis of group A Streptococcus.The Journal of clinical investigation · 2009Review
- Genetic relationships deduced from emm and multilocus sequence typing of invasive Streptococcus dysgalactiae subsp. equisimilis and S. canis recovered from isolates collected in the United States.Journal of clinical microbiology · 2009Article
- Population biology of the human restricted pathogen, Streptococcus pyogenes.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Review
- Superiority of D-zone Testing Method over Standard Method to detect Rnducible Resistance in Gram Positive Bacteria: a Prospective Surveillance from a Teaching Hospital in Saudi Arabia.International journal of health sciences · 2008Article
- Plasmid-Borne erm(T) from invasive, macrolide-resistant Streptococcus pyogenes strains.Antimicrobial agents and chemotherapy · 2008Article
- New genetic element carrying the erythromycin resistance determinant erm(TR) in Streptococcus pneumoniae.Antimicrobial agents and chemotherapy · 2008Article
- Identification of Streptococcus uberis multilocus sequence types highly associated with mastitis.Applied and environmental microbiology · 2008Article
- Review
- Tetracycline resistance in group a streptococci: emergence on a global scale and influence on multiple-drug resistance.Antimicrobial agents and chemotherapy · 2007Article
- Population genetics and linkage analysis of loci within the FCT region of Streptococcus pyogenes.Journal of bacteriology · 2007Article
- M.SpyI, a DNA methyltransferase encoded on a mefA chimeric element, modifies the genome of Streptococcus pyogenes.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Macrolide-resistant group A streptococci (MRGAS) have been recovered from many countries worldwide. However, the strain typing information that is available has been insufficient for estimating the total number of macrolide-resistant clones, their geographic distributions, and their evolutionary relationships. In this study, sequence-based strain typing was used to characterize 212 MRGAS isolates from 34 countries. Evaluation of clonal complexes, emm type, and resistance gene content [erm(A), erm(B), mef(A), and undefined] indicate that macrolide resistance was acquired by GAS organisms via > or independent genetic events. In contrast to other collections of mostly susceptible GAS, genetic diversification of MRGAS clones has occurred primarily by mutation rather than by recombination. Twenty-two MRGAS clonal complexes were recovered from more than one continent; intercontinental strains represent nearly 80% of the MRGAS isolates under study. The findings suggest that horizontal transfer of macrolide resistance genes to numerous genetic backgrounds and global dissemination of resistant clones and their descendants are both major components of the present-day macrolide resistance problem found within this species.
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