ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2006
Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 197 citations in OpenAlex.
- The role of virtual reality in improving motor performance as revealed by EEG: a randomized clinical trial.Journal of neuroengineering and rehabilitation · 2017Trial
- Review: spinal shock, crossed extensor reflex, and mass reflex in dogs and cats-a literature review, clinical observations and considerations.Frontiers in veterinary science · 2026Review
- Changes in intra- and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats.The Journal of physiology · 2024Article
- Construction of a Searchable Database for Gene Expression Changes in Spinal Cord Injury Experiments.Journal of neurotrauma · 2024Article
- Changes in intra- and interlimb reflexes from hindlimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats.The Journal of physiology · 2024Article
- Changes in intra- and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats.bioRxiv : the preprint server for biology · 2024Article
- Targeting astrocytes polarization after spinal cord injury: a promising direction.Frontiers in cellular neuroscience · 2024Review
- Electrical stimulation of the cuneiform nucleus enhances the effects of rehabilitative training on locomotor recovery after incomplete spinal cord injury.Frontiers in neuroscience · 2024Article
- Metformin Improves Functional Outcomes, Activates Neural Precursor Cells, and Modulates Microglia in a Sex-Dependent Manner After Spinal Cord Injury.Stem cells translational medicine · 2023Article
- Prevalence of spasticity in humans with spinal cord injury with different injury severity.Journal of neurophysiology · 2022Article
- Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury.Science China. Life sciences · 2022Article
- Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury.Frontiers in pharmacology · 2022Article
- Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury.Experimental brain research · 2021Article
- Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury.Frontiers in pharmacology · 2021Review
- Regeneration inFrontiers in cell and developmental biology · 2021Review
- Collagen scaffold combined with human umbilical cord-mesenchymal stem cells transplantation for acute complete spinal cord injury.Neural regeneration research · 2020Article
- Axon growth and synaptic function: A balancing act for axonal regeneration and neuronal circuit formation in CNS trauma and disease.Developmental neurobiology · 2020Review
- Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury.The Journal of clinical investigation · 2020Article
- Functional Electrical Stimulation and the Modulation of the Axon Regeneration Program.Frontiers in cell and developmental biology · 2020Review
- Blocking Notch signal pathway suppresses the activation of neurotoxic A1 astrocytes after spinal cord injury.Cell cycle (Georgetown, Tex.) · 2019Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) injuries are particularly traumatic, owing to the limited capabilities of the mammalian CNS for repair. Nevertheless, functional recovery is observed in patients and experimental animals, but the degree of recovery is variable. We review the crucial characteristics of mammalian spinal cord function, tract development, injury and the current experimental therapeutic approaches for repair. Regenerative or compensatory growth of neurites and the formation of new, functional circuits require spontaneous and experimental reactivation of developmental mechanisms, suppression of the growth-inhibitory properties of the adult CNS tissue and specific targeted activation of new connections by rehabilitative training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.