ArticleCardiovascular diabetology2006
Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetes.
Article in Cardiovascular diabetology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Exploring the Relationship between Plasma Adiponectin, Gender, and Underlying Diseases in Severe Illness.Biomedicines · 2023Article
- Review
- IL-10 Dysregulation Underlies Chemokine Insufficiency, Delayed Macrophage Response, and Impaired Healing in Diabetic Wounds.The Journal of investigative dermatology · 2022Article
- Chemokines in Type 1 Diabetes Mellitus.Frontiers in immunology · 2021Article
- Possible mechanisms involved in improved beta cell function in pregnant women with type 1 diabetes.Heliyon · 2020Article
- Adipokines in Liver Cirrhosis.International journal of molecular sciences · 2017Review
- Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue.EMBO reports · 2017Article
- The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter.Molecular nutrition & food research · 2016Article
- Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population.Therapeutic advances in chronic disease · 2015Review
- Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Effects of fenofibrate on adiponectin expression in retinas of streptozotocin-induced diabetic rats.Journal of diabetes research · 2014Article
- Difference in the ratio of high-molecular weight (HMW) to total adiponectin and HMW adiponectin in late post-menopausal women.Journal of endocrinological investigation · 2013Article
- Adiponectin, a key adipokine in obesity related liver diseases.World journal of gastroenterology · 2011Review
- Adiponectin levels and expression of adiponectin receptors in isolated monocytes from overweight patients with coronary artery disease.Cardiovascular diabetology · 2011Article
- Article
- Dysregulation of maternal serum adiponectin in preterm labor.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2009Article
- Maternal serum adiponectin multimers in preeclampsia.Journal of perinatal medicine · 2009Article
- Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn.Journal of perinatal medicine · 2009Article
- Adiponectin multimers in maternal plasma.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008Article
- Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms.Current genomics · 2008Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSystemic adiponectin is reduced in patients with cardiovascular disease (CVD) and low adiponectin may contribute to the pathogenesis of atherosclerosis. However, circulating adiponectin is elevated in type 1 diabetes (T1D) patients, who have also a higher incidence to develop CVD. Because monocytes play an important role in atherosclerosis, we analysed the influence of adiponectin on cytokine and chemokine release in monocytes from T1D patients and controls.
methodsSystemic adiponectin was determined in the plasma and the high-molecular weight (HMW) form of adiponectin was analysed by immunoblot. Monocytes were isolated from T1D patients and controls and the adiponectin-stimulated release of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) was analysed.
resultsSystemic adiponectin was higher in T1D patients. Immunoblot analysis of the plasma indicate abundance of HMW adiponectin in T1D patients and controls. IL-6, CCL2 and CXCL8 secretion in response to adiponectin were found induced in monocytes from controls whereas only IL-6 was upregulated in T1D cells. The induction of IL-6 by adiponectin was abrogated by an inhibitor of the NFkappaB pathway.
conclusionThese data indicate that adiponectin-mediated induction of IL-6, CCL2 and CXCL8 is disturbed in monocytes from T1D patients and therefore elevated systemic adiponectin in T1D patients may be less protective when compared to controls.
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