ArticleBMC genomics2006
Gene order data from a model amphibian (Ambystoma): new perspectives on vertebrate genome structure and evolution.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The Complete Mitochondrial Genome of a Natural Triploid Crucian Carp Mutant,Life (Basel, Switzerland) · 2025Article
- Gene and transgenics nomenclature for the laboratory axolotl-Ambystoma mexicanum.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Why Do Some Vertebrates Have Microchromosomes?Cells · 2021Review
- A chromosome-scale assembly of the axolotl genome.Genome research · 2019Article
- Miniscule differences between sex chromosomes in the giant genome of a salamander.Scientific reports · 2018Article
- Review
- A linkage map for the Newt Notophthalmus viridescens: Insights in vertebrate genome and chromosome evolution.Developmental biology · 2017Article
- Initial characterization of the large genome of the salamander Ambystoma mexicanum using shotgun and laser capture chromosome sequencing.Scientific reports · 2015Article
- The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications.Genome research · 2015Article
- Article
- Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.Nature genetics · 2013Article
- Genomics of a metamorphic timing QTL: met1 maps to a unique genomic position and regulates morph and species-specific patterns of brain transcription.Genome biology and evolution · 2013Article
- Article
- First-generation linkage map for the common frog Rana temporaria reveals sex-linkage group.Heredity · 2011Article
- Origin of amphibian and avian chromosomes by fission, fusion, and retention of ancestral chromosomes.Genome research · 2011Article
- Preparation of Xenopus tropicalis whole chromosome painting probes using laser microdissection and reconstruction of X. laevis tetraploid karyotype by Zoo-FISH.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Article
- Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement.Genome research · 2008Article
- Comparative chromosome mapping of sex-linked genes and identification of sex chromosomal rearrangements in the Japanese wrinkled frog (Rana rugosa, Ranidae) with ZW and XY sex chromosome systems.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Bird and mammal sex-chromosome orthologs map to the same autosomal region in a salamander (ambystoma).Genetics · 2007Article
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Abstract
backgroundBecause amphibians arise from a branch of the vertebrate evolutionary tree that is juxtaposed between fishes and amniotes, they provide important comparative perspective for reconstructing character changes that have occurred during vertebrate evolution. Here, we report the first comparative study of vertebrate genome structure that includes a representative amphibian. We used 491 transcribed sequences from a salamander (Ambystoma) genetic map and whole genome assemblies for human, mouse, rat, dog, chicken, zebrafish, and the freshwater pufferfish Tetraodon nigroviridis to compare gene orders and rearrangement rates.
resultsAmbystoma has experienced a rate of genome rearrangement that is substantially lower than mammalian species but similar to that of chicken and fish. Overall, we found greater conservation of genome structure between Ambystoma and tetrapod vertebrates, nevertheless, 57% of Ambystoma-fish orthologs are found in conserved syntenies of four or more genes. Comparisons between Ambystoma and amniotes reveal extensive conservation of segmental homology for 57% of the presumptive Ambystoma-amniote orthologs.
conclusionOur analyses suggest relatively constant interchromosomal rearrangement rates from the euteleost ancestor to the origin of mammals and illustrate the utility of amphibian mapping data in establishing ancestral amniote and tetrapod gene orders. Comparisons between Ambystoma and amniotes reveal some of the key events that have structured the human genome since diversification of the ancestral amniote lineage.
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