ArticleProceedings of the National Academy of Sciences of the United States of America2006
Broad activation of the olfactory bulb produces long-lasting changes in odor perception.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 87 citations in OpenAlex.
- Olfactory function and an explanatory model of pica revealed through a case report.Journal of eating disorders · 2026Article
- Deletion of NPAS4 in olfactory bulb principal neurons alters E/I balance and impairs decoding of chemically similar odour molecules.The Journal of physiology · 2026Article
- Dopaminergic short axon cells integrate sensory and top-down inputs to enhance discriminative learning in the mouse olfactory bulb.PLoS biology · 2025Article
- Wider Than the Sky: An Alternative to "Mapping" the World Onto the Brain.The European journal of neuroscience · 2025Article
- Physicochemical features partially explain olfactory crossmodal correspondences.Scientific reports · 2023Article
- Article
- COVID-19 and olfactory dysfunction: a looming wave of dementia?Journal of neurophysiology · 2022Review
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis.iScience · 2019Article
- Short-term availability of adult-born neurons for memory encoding.Nature communications · 2019Article
- Noradrenergic effects on olfactory perception and learning.Brain research · 2019Review
- Article
- Physical Interaction Is Required in Social Buffering Induced by a Familiar Conspecific.Scientific reports · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Olfactory perceptual learning requires action of noradrenaline in the olfactory bulb: comparison with olfactory associative learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Distinct roles of bulbar muscarinic and nicotinic receptors in olfactory discrimination learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Acid-sensing ion channels in mouse olfactory bulb M/T neurons.The Journal of general physiology · 2014Article
- Effect of odor preexposure on acquisition of an odor discrimination in dogs.Learning & behavior · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of electrophysiological experiments have shown that odor exposure alone, unaccompanied by behavioral training, changes the response patterns of neurons in the olfactory bulb. As a consequence of these changes, across mitral cells in the olfactory bulb, individual odors should be better discriminated because of previous exposure. We have previously shown that a daily 2-h exposure to odorants during 2 weeks enhances rats' ability to discriminate between chemically similar odorants. Here, we first show that the perception of test odorants is only modulated by enrichment with odorants that activate at least partially overlapping regions of the olfactory bulb. Second, we show that a broad activation of olfactory bulb neurons by daily local infusion of NMDA into both olfactory bulbs enhances the discrimination between chemically related odorants in a manner similar to the effect of daily exposure to odorants. Computational modeling of the olfactory bulb suggests that activity-dependent plasticity in the olfactory bulb can support the observed modulation in olfactory discrimination capability by enhancing contrast and synchronization in the olfactory bulb. Last, we show that blockade of NMDA receptors in the olfactory bulb impairs the effects of daily enrichment, suggesting that NMDA-dependent plasticity is involved in the changes in olfactory processing observed here.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.