ArticleProceedings of the National Academy of Sciences of the United States of America2006
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Contribution of neurons that expressiScience · 2025Article
- Protein Stores Regulate When Reproductive Displays Begin in the Male Caribbean Fruit Fly.Frontiers in physiology · 2020Article
- Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons.PLoS genetics · 2019Article
- Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons.Journal of neuroinflammation · 2018Article
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- Inositols affect the mating circadian rhythm of Drosophila melanogaster.Frontiers in pharmacology · 2015Article
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- A PDF/NPF neuropeptide signaling circuitry of male Drosophila melanogaster controls rival-induced prolonged mating.Neuron · 2013Article
- Glutathione peroxidase activity is neuroprotective in models of Huntington's disease.Nature genetics · 2013Article
- A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.Frontiers in cellular neuroscience · 2013Article
- What can Drosophila teach us about iron-accumulation neurodegenerative disorders?Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- The sex-biased brain: sexual dimorphism in gene expression in two species of songbirds.BMC genomics · 2011Article
- Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila.BMC genomics · 2010Article
- Circadian organization of behavior and physiology in Drosophila.Annual review of physiology · 2010Review
- Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster.PloS one · 2009Article
- Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues.PLoS genetics · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
To investigate the functions of circadian neurons, we added two strategies to the standard Drosophila behavioral genetics repertoire. The first was to express a polyglutamine-expanded neurotoxic protein (MJDtr78Q; MJD, Machado-Joseph disease) in the major timeless (tim)-expressing cells of the adult brain. These Tim-MJD flies were viable, in contrast to the use of cell-death gene expression for tim neuron inactivation. Moreover, they were more arrhythmic than flies expressing other neurotoxins and had low but detectable tim mRNA levels. The second extended standard microarray technology from fly heads to dissected fly brains. By combining the two approaches, we identified a population of Tim-MJD-affected mRNAs. Some had been previously identified as sex-specific and relevant to courtship, including mRNAs localized to brain-proximal fat-body tissue and brain courtship centers. Finally, we found a decrease in the number of neurons that expressed male-specific forms of the fruitless protein in the laterodorsal region of the brain. The decrease was not a consequence of toxic protein expression within these specialized cells but a likely effect of communication with neighboring TIM-expressing neurons. The data suggest a functional interaction between adjacent circadian and mating circuits within the fly brain, as well as an interaction between circadian circuits and brain-proximal fat body.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.