ArticleProceedings of the National Academy of Sciences of the United States of America2006
A mitotically inheritable unit containing a MAP kinase module.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- The NADPH Oxidase A ofJournal of fungi (Basel, Switzerland) · 2021Article
- Crosstalk Between Pheromone Signaling and NADPH Oxidase Complexes Coordinates Fungal Developmental Processes.Frontiers in microbiology · 2020Article
- A RID-like putative cytosine methyltransferase homologue controls sexual development in the fungus Podospora anserina.PLoS genetics · 2019Article
- A homologue of the fungal tetraspanin Pls1 is required for Epichloë festucae expressorium formation and establishment of a mutualistic interaction with Lolium perenne.Molecular plant pathology · 2019Article
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- New insights from an old mutant: SPADIX4 governs fruiting body development but not hyphal fusion in Sordaria macrospora.Molecular genetics and genomics : MGG · 2017Article
- Article
- Functional characterization of the three mitogen-activated protein kinase kinases (MAP2Ks) present in the Cryphonectria parasitica genome reveals the necessity of Cpkk1 and Cpkk2, but not Cpkk3, for pathogenesis on chestnut (Castanea spp.).Molecular plant pathology · 2014Article
- Similar and distinct roles of NADPH oxidase components in the tangerine pathotype of Alternaria alternata.Molecular plant pathology · 2013Article
- A network of HMG-box transcription factors regulates sexual cycle in the fungus Podospora anserina.PLoS genetics · 2013Article
- Rab-GDI complex dissociation factor expressed through translational frameshifting in filamentous ascomycetes.PloS one · 2013Article
- The NADPH oxidase-mediated production of hydrogen peroxide (H(2)O(2)) and resistance to oxidative stress in the necrotrophic pathogen Alternaria alternata of citrus.Molecular plant pathology · 2012Article
- A non-Mendelian MAPK-generated hereditary unit controlled by a second MAPK pathway in Podospora anserina.Genetics · 2012Article
- Potential roles for prions and protein-only inheritance in cancer.Cancer metastasis reviews · 2012Review
- Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.Annual review of biochemistry · 2009Review
- Article
- Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures.BioEssays : news and reviews in molecular, cellular and developmental biology · 2008Review
- The genome sequence of the model ascomycete fungus Podospora anserina.Genome biology · 2008Article
- PaTrx1 and PaTrx3, two cytosolic thioredoxins of the filamentous ascomycete Podospora anserina involved in sexual development and cell degeneration.Eukaryotic cell · 2007Article
- Mitogen-activated protein kinase pathways and fungal pathogenesis.Eukaryotic cell · 2007Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prions are novel kinds of hereditary units, relying solely on proteins, that are infectious and inherited in a non-Mendelian fashion. To date, they are either based on autocatalytic modification of a 3D conformation or on autocatalytic cleavage. Here, we provide further evidence that in the filamentous fungus Podospora anserina, a MAP kinase cascade is probably able to self-activate and generate C, a hereditary unit that bears many similarities to prions and triggers cell degeneration. We show that in addition to the MAPKKK gene, both the MAPKK and MAPK genes are necessary for the propagation of C, and that overexpression of MAPK as that of MAPKKK facilitates the appearance of C. We also show that a correlation exists between the presence of C and localization of the MAPK inside nuclei. These data emphasize the resemblance between prions and a self-positively regulated cascade in terms of their transmission. This thus further expands the concept of protein-base inheritance to regulatory networks that have the ability to self-activate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.