ReviewBrain and language2007
Some problems for representations of brain organization based on activation in functional imaging.
Review in Brain and language, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Therapeutic high-frequency stimulation of the subthalamic nucleus in Parkinson's disease produces global increases in cerebral blood flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas.Biology of sex differences · 2023Article
- Affective Prosody and Its Impact on the Neurology of Language, Depression, Memory and Emotions.Brain sciences · 2023Review
- Oromotor Nonverbal Performance and Speech Motor Control: Theory and Review of Empirical Evidence.Brain sciences · 2023Review
- Cerebral Blood Flow Is Not a Direct Surrogate of Behavior: Performance Models Suggest a Role for Functional Meta-Networks.Frontiers in neuroscience · 2022Article
- Genotypic Differences in Networks Supporting Regional Predictors of Speech Rate in Spinocerebellar Ataxia: Preliminary Observations.Brain connectivity · 2021Article
- A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers.Brain structure & function · 2019Article
- Cortical-subcortical production of formulaic language: A review of linguistic, brain disorder, and functional imaging studies leading to a production model.Brain and cognition · 2018Review
- Switching Language Modes: Complementary Brain Patterns for Formulaic and Propositional Language.Brain connectivity · 2018Article
- Towards a healthy human model of neural disorders of movement.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2012Article
- Performance-based connectivity analysis: a path to convergence with clinical studies.NeuroImage · 2012Article
- A lifespan perspective on semantic processing of concrete concepts: does a sensory/motor model have the potential to bridge the gap?Cognitive, affective & behavioral neuroscience · 2011Review
- Longitudinal cerebral blood flow changes during speech in hereditary ataxia.Brain and language · 2010Article
- Effects of neurological damage on production of formulaic language.Clinical linguistics & phonetics · 2009Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
Functional brain imaging has overshadowed traditional lesion studies in becoming the dominant approach to the study of brain-behavior relationships. The proponents of functional imaging studies frequently argue that this approach provides an advantage over lesion studies by observing normal brain activity in vivo without the disruptive effects of brain damage. However, the enthusiastic onslaught of brain images, frequently presented as veridical representations of mental function, has sometimes overwhelmed some basic facts about brain organization repeatedly observed over more than a century. In particular, the lateralization of speech and language to the left cerebral hemisphere in over 90% of the right-handed population does not appear to have been taken as a serious constraint in the interpretation of imaging results in studies of these functions. This paper reviews a number of areas in which standard activation assumptions yield results that are at odds with clinical experience. The activation approach will be contrasted with a performance-based analysis of functional image data, which, at least in the case of speech production, yields results in better agreement with lesion data. Functional imaging represents enormous opportunities for understanding brain-behavior relationships, but at the present level of understanding of what is being represented in such images, it is premature to adhere to a single approach based on the strong but questionable assumptions inherent in most activation studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.