Evidence map›Paper›PMID 16937502›Full record

ArticleWorld journal of gastroenterology2006

Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer.

George Theodoropoulos, Ioannis Papaconstantinou, Evangelos Felekouras, Nikolaos Nikiteas, Petros Karakitsos, Dimitris Panoussopoulos, Andreas Ch Lazaris, Efstratios Patsouris, John Bramis, Maria Gazouli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 19 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 19 syntheses or guidelines pooled it, 129 citations in OpenAlex.

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  4. A trial sequential meta-analysis ofBioscience reports · 2019
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  6. Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
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  7. Association of Polymorphisms in Intercellular Adhesion Molecule 1 (ICAM-1) Gene with Cancer Susceptibility: A Meta-Analysis of 14 Case-Control Studies.Medical science monitor : international medical journal of experimental and clinical research · 2016
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  10. Effect of Proliferator-Activated Receptor-γ Pro12Ala Polymorphism on Colorectal Cancer Risk: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
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  11. The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  20. Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Trial

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

George Theodoropoulos1st Propaideutic Surgical Department, Hippocration University Hospital, University of Athens, Greece.
Ioannis Papaconstantinou
Evangelos Felekouras
Nikolaos Nikiteas
Petros Karakitsos
Dimitris Panoussopoulos
Andreas Ch Lazaris
Efstratios Patsouris
John Bramis
Maria Gazouli
Hippocration General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the association between common single nucleotide polymorphisms (SNPs) in inflammatory response-related genes such as interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNFalpha), peroxisome proliferators-activated receptor gamma (PPARgamma), intercellular adhesion molecule-1 (ICAM-1) and the risk of colorectal cancer (CRC) in a group of Greek patients.

methodsThe study group consisted of 222 CRC patients and 200 healthy controls. Genotyping was performed using allele-specific PCR of PRC-RFLP and the results were confirmed by sequencing. We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E), and PPARgamma (Pro12Ala) genes and the risk of CRC.

resultsThe IL-6 -174G, R241 and K469 alleles of ICAM-1 were associated with increased risk of CRC (OR = 1.77, 95% CI: 1.34-2.34; OR = 1.83, 95% CI: 1.23-2.72; and OR = 1.35, 95% CI: 1.03-1.77 respectively). The IL-8 and TNFalpha polymorphisms had no effect. Whereas the PPARgamma Pro12 genotype was associated with increased risk of disease (OR = 1.78, 95% CI: 1.25-2.49).

conclusionThe association between common SNPs in immunologic response-related genes and CRC is reported in the present study. Apart from shedding light on the mechanisms of malignancy initiation and progression, SNPs may improve appropriate screening for sub-populations at risk.

Indexed as

Polymorphism, GeneticPolymorphism, Single NucleotideAgedColorectal NeoplasmsFemaleGenotypeGreeceHumansInflammationIntercellular Adhesion Molecule-1Interleukin-6Interleukin-8MaleMiddle AgedPPAR gammaTumor Necrosis Factor-alphaIntercellular Adhesion Molecule-1Interleukin-6Interleukin-8PPAR gammaTumor Necrosis Factor-alpha

Identifiers

PMID16937502
PMCPMC4087409
OpenAlexW238827458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.