ReviewWorld journal of gastroenterology2006
Insights on augmenter of liver regeneration cloning and function.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- ALR inhibits HBV replication and autophagosome formation by ameliorating HBV-induced ROS production in hepatic cells.Virus genes · 2025Article
- Augmenter of Liver Regeneration Monoclonal Antibody Promotes Apoptosis of Hepatocellular Carcinoma Cells.Journal of clinical and translational hepatology · 2023Article
- Liposome cocktail activator modulates hepatocytes and remodels the microenvironment to mitigate acute liver failure.Asian journal of pharmaceutical sciences · 2022Article
- Dysregulation of Liver Regeneration by Hepatitis B Virus Infection: Impact on Development of Hepatocellular Carcinoma.Cancers · 2022Review
- Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways.PloS one · 2017Article
- Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis.Neurochemical research · 2014Review
- High expression of 23 kDa protein of augmenter of liver regeneration (ALR) in human hepatocellular carcinoma.OncoTargets and therapy · 2014Article
- Human augmenter of liver regeneration: probing the catalytic mechanism of a flavin-dependent sulfhydryl oxidase.Biochemistry · 2013Article
- Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration.Molecular medicine (Cambridge, Mass.) · 2013Article
- Hepatic stimulator substance alleviates toxin-induced and immune-mediated liver injury and fibrosis in rats.Digestive diseases and sciences · 2012Article
- Augmenter of liver regeneration (alr) promotes liver outgrowth during zebrafish hepatogenesis.PloS one · 2012Article
- Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells.Molecular biology of the cell · 2011Article
- Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy .Biochemistry · 2010Article
- A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells.Autophagy · 2010Article
- Involvement of hepatic stimulator substance in experimentally induced fibrosis and cirrhosis in the rat.Digestive diseases and sciences · 2009Article
- Transcriptome analysis of Frog virus 3, the type species of the genus Ranavirus, family Iridoviridae.Virology · 2009Article
- Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space.Biochemistry · 2009Article
- The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.American journal of human genetics · 2009Article
- Genetic recombinant expression and characterization of human augmenter of liver regeneration.Digestive diseases and sciences · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic stimulator substance (HSS) has been referred to as a liver-specific but species non-specific growth factor. Gradient purification and sequence analysis of HSS protein indicated that it contained the augmenter of liver regeneration (ALR), also known as hepatopoietin (HPO). ALR, acting as a hepatotrophic growth factor, specifically stimulated proliferation of cultured hepatocytes as well as hepatoma cells in vitro, promoted liver regeneration and recovery of damaged hepatocytes and rescued acute hepatic failure in vivo. ALR belongs to the new Erv1/Alr protein family, members of which are found in lower and higher eukaryotes from yeast to man and even in some double-stranded DNA viruses. The present review article focuses on the molecular biology of ALR, examining the ALR gene and its expression from yeast to man and the biological function of ALR protein. ALR protein seems to be non-liver-specific as was previously believed, increasing the necessity to extend research on mammalian ALR protein in different tissues, organs and developmental stages in conditions of normal and abnormal cellular growth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.