ArticleWorld journal of gastroenterology2006
Effects of Ca2+ channel blockers on store-operated Ca2+ channel currents of Kupffer cells after hepatic ischemia/reperfusion injury in rats.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 82 citations in OpenAlex.
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- Action of econazole on CaJournal of dental sciences · 2023Article
- TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species.Antioxidants (Basel, Switzerland) · 2021Review
- Interaction Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Disease.Frontiers in psychiatry · 2021Article
- Mechanism of a methylxanthine drug theophylline-induced CaToxicology research · 2020Article
- Na-K-2Cl Cotransporter and Store-Operated CaBiophysical journal · 2019Article
- Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies.Journal of biomedical research · 2019Article
- Metformin Reduces Lipotoxicity-Induced Meta-Inflammation inJournal of diabetes research · 2019Article
- Ca(2+) movement and apoptosis induced by deltamethrin in Madin-Darby canine kidney canine renal tubular cells.The Kaohsiung journal of medical sciences · 2015Article
- Interfacial stress affects rat alveolar type II cell signaling and gene expression.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Effects and mechanisms of store-operated calcium channel blockade on hepatic ischemia-reperfusion injury in rats.World journal of gastroenterology · 2012Article
- Ischemia/Reperfusion injury in liver surgery and transplantation: pathophysiology.HPB surgery : a world journal of hepatic, pancreatic and biliary surgery · 2012Article
- Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug.PloS one · 2011Article
- Plasma membrane calcium ATPase isoform 3 expression in single cells isolated from rat liver.Molecular and cellular biochemistry · 2010Article
- Mechanisms of carvedilol-induced [Ca2+] i rises and death in human hepatoma cells.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effects of hepatic ischemia/reperfusion (I/R) injury on store-operated calcium channel (SOC) currents (I(SOC)) in freshly isolated rat Kupffer cells, and the effects of Ca(2+) channel blockers, 2-aminoethoxydiphenyl borate (2-APB), SK and F96365, econazole and miconazole, on I(SOC) in isolated rat Kupffer cells after hepatic I/R injury.
methodsThe model of rat hepatic I/R injury was established. Whole-cell patch-clamp techniques were performed to investigate the effects of 2-APB, SK and F96365, econazole and miconazole on I(SOC) in isolated rat Kupffer cells after hepatic I /R injury.
resultsI/R injury significantly increased I(SOC) from -80.4 +/- 25.2pA to -159.5 +/- 34.5pA ((b)P < 0.01, n = 30). 2-APB (20, 40, 60, 80, 100 micromol/L), SK and F96365 (5, 10, 20, 40, 50 micromol/L), econazole (0.1, 0.3, 1, 3, 10 micromol/L) and miconazole (0.1, 0.3, 1, 3, 10 micromol/L) inhibited I(SOC) in a concentration-dependent manner with IC50 of 37.41 micromol/L (n = 8), 5.89 micromol/L (n = 11), 0.21 micromol/L (n = 13), and 0.28 micromol/L (n = 10). The peak value of I(SOC) in the I-V relationship was decreased by the blockers in different concentrations, but the reverse potential of I(SOC) was not transformed.
conclusionSOC is the main channel for the influx of Ca(2+) during hepatic I/R injuries. Calcium channel blockers, 2-APB, SK and F96365, econazole and miconazole, have obviously protective effects on I/R injury, probably by inhibiting I(SOC) in Kupffer cells and preventing the activation of Kupffer cells.
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