ArticleWorld journal of gastroenterology2006
Efficacy of ultrasonography and alpha-fetoprotein on early detection of hepatocellular carcinoma.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 31 citations in OpenAlex.
- Utility of Alpha-Fetoprotein and Ultrasound in the Diagnosis and Prognosis of Patients with Hepatocellular Liver Cancer.Journal of multidisciplinary healthcare · 2024Article
- Hepatocellular carcinoma screening and surveillance in 2293 chronic hepatitis B patients in an endemic area.World journal of gastroenterology · 2016Article
- Prospective screening increases the detection of potentially curable hepatocellular carcinoma: results in 8,900 high-risk patients.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2013Article
- Cirrhosis and Chronic Viral Hepatitis as Risk Factors for Hepatocellular Carcinoma: Romanian Single-clinic Experience.Maedica · 2010Article
- Treatment of liver hydatidosis: how to treat an asymptomatic carrier?World journal of gastroenterology · 2010Article
- Chronic viral hepatitis and hepatocellular carcinoma.World journal of surgery · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effectiveness of ultrasonographic screening for early detection of hepatocellular carcinoma (HCC).
methodsThe data of 14968 patients who had ultrasonography (US) for chronic liver diseases were collected into a database program from June 1995 to June 2005. The risk factors for HCC were also studied. A total of 6089 patients who had repeated US were enrolled, 264 patients were diagnosed with HCC during follow-up (mean, 39 mo).
resultsThe detection rate of small HCC (<= 3 cm in diameter) was 67.7%. The tumor size detected by screening at the intervals of 6 mo was significantly smaller than that at longer intervals. Only 29.3% of HCC patients had an elevated serum alpha fetoprotein (AFP) level above 400 ng/mL. The risk of HCC development during follow-up was higher in patients with liver cirrhosis (10.9%) and hepatitis C (9.0%) than in patients with chronic hepatitis (4.2%), hepatitis B (4.9%) and non-B, non-C hepatitis (NBNC, 3.9%).
conclusionUS screening at a interval of 6 mo is beneficial to high-risk patients over 40 years old and the early detection of HCC prolongs survival.
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