Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells.Advances in neurobiology · 2020
   Review
2. FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.Molecular psychiatry · 2018
   Article
3. Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.Progress in neurobiology · 2016
   Review
4. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.Cell reports · 2015
   Article
5. Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells.Biological psychiatry · 2014
   Review
6. DISC1 genetics, biology and psychiatric illness.Frontiers in biology · 2013
   Article
7. Linking neurodevelopmental and synaptic theories of mental illness through DISC1.Nature reviews. Neuroscience · 2011
   Review
8. What is a functional genetic polymorphism? Defining classes of functionality.Journal of psychiatry & neuroscience : JPN · 2011
   Article
9. Elevated DISC1 transcript levels in PBMCs during acute psychosis in patients with schizophrenia.Translational biomedicine · 2011
   Article
10. Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008
    Article
11. Association of DISC1 with autism and Asperger syndrome.Molecular psychiatry · 2008
    Article
12. The DISC locus in psychiatric illness.Molecular psychiatry · 2008
    Review
13. The genetic deconstruction of psychosis.Schizophrenia bulletin · 2007
    Review

Corrections and comments

• Comment on
  A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder.2005

Authors and funding

8 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as