ReviewOncogene2006
Regulation of cell lineage specification by the retinoblastoma tumor suppressor.
Review in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- TargetingCancers · 2021Review
- RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling.The Plant cell · 2013Article
- Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function.The Journal of biological chemistry · 2012Article
- p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanisms.Molecular and cellular biology · 2012Article
- PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein.Oncogene · 2011Article
- Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma.PloS one · 2011Article
- Article
- A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling.Stem cell reviews and reports · 2010Article
- Retinal horizontal cells: challenging paradigms of neural development and cancer biology.Development (Cambridge, England) · 2009Review
- Article
- Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells.Neural development · 2009Article
- Regulation of the retinoblastoma proteins by the human herpesviruses.Cell division · 2009Article
- Caspase 6 regulates B cell activation and differentiation into plasma cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cellular mechanisms of tumour suppression by the retinoblastoma gene.Nature reviews. Cancer · 2008Review
- Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Regulation of B-cell entry into the cell cycle.Immunological reviews · 2008Review
- Epigenetics in assisted reproductive technology.Reproductive medicine and biology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator of the G(1)/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and nematodes have also shown RB controls cell lineage specification and aspects of differentiation. The RB gene product accomplishes this by diverse mechanisms such as by interacting with tissue-specific transcription factors, enhancing RNA interference, and modifying chromatin structure. We review recent studies uncovering novel mechanisms by which RB works in several cell lineages and we provide perspectives on how these new findings might relate to RB tumor suppression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.