ReviewOncogene2006
Regulation of cellular senescence by Rb2/p130.
Review in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Suppression of Ribose-5-Phosphate Isomerase a Induces ROS to Activate Autophagy, Apoptosis, and Cellular Senescence in Lung Cancer.International journal of molecular sciences · 2022Article
- Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs.International journal of molecular sciences · 2022Review
- Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.Molecular cancer research : MCR · 2020Article
- Cell senescence in myxoid/round cell liposarcoma.Sarcoma · 2014Article
- Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.Cellular and molecular life sciences : CMLS · 2013Article
- Reprogramming of fibroblasts from older women with pelvic floor disorders alters cellular behavior associated with donor age.Stem cells translational medicine · 2013Article
- p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability.Molecular and cellular biology · 2012Article
- Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.The EMBO journal · 2012Article
- Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence.Oncogene · 2009Article
- pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda.BMC clinical pathology · 2009Article
- Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.Oncogene · 2008Article
- Melanomagenesis: overcoming the barrier of melanocyte senescence.Cell cycle (Georgetown, Tex.) · 2008Review
- Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts.Aging cell · 2008Article
- Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice.Molecular vision · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth regulatory functions of Rb2/p130, which aim at a sustained arrest such as in quiescent or differentiated cells, qualify the protein also to act as a central regulator of growth arrest in cellular senescence. In this respect, Rb2/p130 functions are connected to signaling pathways induced by p53, which is a master regulator in cellular senescence. Here, we summarize the pathways, which specify pRb2/p130 to control this arrest program and distinguish its functions from those of pRb/p105.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.