ArticleThe American journal of pathology2006
Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potential.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Role of Organ-Specific Endothelial Cells in Melanoma Adhesion Patterns.Biomedicines · 2026Article
- Tumor Metastasis in the Microcirculation.Advances in experimental medicine and biology · 2026Review
- The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer.Gastro hep advances · 2025Review
- Striated muscle: an inadequate soil for cancers.Cancer metastasis reviews · 2024Review
- A case of solitary metastatic colon adenocarcinoma of the sternum: an unusual metastatic site.Journal of surgical case reports · 2024Article
- Utilizing machine learning algorithms for predicting risk factors for bone metastasis from right-sided colon carcinoma after complete mesocolic excision: a 10-year retrospective multicenter study.Discover oncology · 2024Article
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- Intravital imaging to study cancer progression and metastasis.Nature reviews. Cancer · 2023Review
- Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study.Frontiers in surgery · 2022Article
- Survival outcome and prognostic factors for colorectal cancer with synchronous bone metastasis: a population-based study.Clinical & experimental metastasis · 2021Article
- Cross Talk Between Macrophages and Cancer Cells in the Bone Metastatic Environment.Frontiers in endocrinology · 2021Review
- Cervical bone pain revealing a bone metastatic colon cancer: A case report.Molecular and clinical oncology · 2020Article
- Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness.Scientific reports · 2020Article
- Metastatic colorectal carcinoma initially diagnosed by bone marrow biopsy: a case report and literature review.Journal of the Egyptian National Cancer Institute · 2020Review
- The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation.Advanced healthcare materials · 2020Review
- Localization of Rolling and Firm-Adhesive Interactions Between Circulating Tumor Cells and the Microvasculature Wall.Cellular and molecular bioengineering · 2020Article
- Article
- Review
- Immunological Regulation of Vascular Inflammation During Cancer Metastasis.Frontiers in immunology · 2019Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesive and invasive characteristics appear to be crucial for organ-specific metastasis formation. Using intravital microscopy we investigated the relation between the metastatic potential of colon carcinoma cells and their adhesive and invasive behavior during early steps of metastasis within microvasculatures of rat liver, lung, intestine, skin, muscle, spleen, and kidney in vivo. Colon carcinoma cells with low (HT-29P), intermediate (KM-12C), and high (HT-29LMM, KM-12L4) metastatic potential were injected into nude or Sprague-Dawley rats. Initial interactions with host organ microvasculatures were semiquantitatively analyzed throughout 20 to 30 minutes. Circulating cells passed microvessels in all observed organs without size restriction. All cell lines showed high adhesion rates, independent from their metastatic potential, within liver and lung but very rarely in other organs. Diameters of involved microvessels were larger than diameters of adherent tumor cells. Cell extravasation of highly metastatic HT-29LMM and KM-12L4 cells into liver parenchyma was significantly higher compared to low metastatic cells (P<0.05). Our results indicate that colon carcinoma cells can arrest in target organs without size restriction. Cell adhesion of circulating tumor cells occurred in metastatic target organs only, likely attributable to specific interactions. Migration into target organs correlated with their metastatic potential.
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