ArticleJournal of bacteriology2006
Genome rearrangements, deletions, and amplifications in the natural population of Bartonella henselae.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
- Epidemiology of Bartonella henselae infection in pet and stray cats in Croatia with risk factors analysis.Parasites & vectors · 2024Article
- Genomic structural plasticity of rodent-associated Bartonella in nature.Molecular ecology · 2022Article
- Long-Read Sequencing Reveals Genetic Adaptation ofFrontiers in microbiology · 2022Article
- Gene Transfer Agents in Symbiotic Microbes.Results and problems in cell differentiation · 2020Review
- Bartonella gene transfer agent: Evolution, function, and proposed role in host adaptation.Cellular microbiology · 2019Review
- Prophage-Driven Genomic Structural Changes Promote Bartonella Vertical Evolution.Genome biology and evolution · 2018Article
- Phylogeny and putative virulence gene analysis of Bartonella bovis.The Journal of veterinary medical science · 2018Article
- Molecular Mechanisms ofFrontiers in cellular and infection microbiology · 2018Review
- An integrative strategy to identify the entire protein coding potential of prokaryotic genomes by proteogenomics.Genome research · 2017Article
- A family of genus-specific RNAs in tandem with DNA-binding proteins control expression of the badA major virulence factor gene in Bartonella henselae.MicrobiologyOpen · 2017Article
- A gene transfer agent and a dynamic repertoire of secretion systems hold the keys to the explosive radiation of the emerging pathogen Bartonella.PLoS genetics · 2013Article
- Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain.PloS one · 2013Article
- Selection-driven gene loss in bacteria.PLoS genetics · 2012Article
- A genome-wide study of recombination rate variation in Bartonella henselae.BMC evolutionary biology · 2012Article
- Multi-locus sequence analysis reveals profound genetic diversity among isolates of the human pathogen Bartonella bacilliformis.PLoS neglected tropical diseases · 2011Article
- Multilocus sequence typing of Bartonella henselae in the United Kingdom indicates that only a few, uncommon sequence types are associated with zoonotic disease.Journal of clinical microbiology · 2011Article
- Horizontal transfer, not duplication, drives the expansion of protein families in prokaryotes.PLoS genetics · 2011Article
- Article
- Improved detection of Bartonella DNA in mammalian hosts and arthropod vectors by real-time PCR using the NADH dehydrogenase gamma subunit (nuoG).Journal of clinical microbiology · 2010Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cats are the natural host for Bartonella henselae, an opportunistic human pathogen and the agent of cat scratch disease. Here, we have analyzed the natural variation in gene content and genome structure of 38 Bartonella henselae strains isolated from cats and humans by comparative genome hybridizations to microarrays and probe hybridizations to pulsed-field gel electrophoresis (PFGE) blots. The variation in gene content was modest and confined to the prophage and the genomic islands, whereas the PFGE analyses indicated extensive rearrangements across the terminus of replication with breakpoints in areas of the genomic islands. We observed no difference in gene content or structure between feline and human strains. Rather, the results suggest multiple sources of human infection from feline B. henselae strains of diverse genotypes. Additionally, the microarray hybridizations revealed DNA amplification in some strains in the so-called chromosome II-like region. The amplified segments were centered at a position corresponding to a putative phage replication initiation site and increased in size with the duration of cultivation. We hypothesize that the variable gene pool in the B. henselae population plays an important role in the establishment of long-term persistent infection in the natural host by promoting antigenic variation and escape from the host immune response.
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