ReviewJournal of clinical pathology2006
Optimal processing of bone marrow trephine biopsy: the Hammersmith Protocol.
Review in Journal of clinical pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 76 citations in OpenAlex.
- Effects of fixation and demineralization on immunohistochemical assessment of canine bone marrow.Veterinary pathology · 2026Article
- Age-Related Alterations in SIBLING Proteins and Dentin Micro-Architecture: Morphological and Molecular Associations.Life (Basel, Switzerland) · 2025Article
- One protocol to rule them all: a pilot study to identify the best fixation and decalcification approach for bone marrow biopsy immunohistochemistry.Pathologica · 2025Article
- Effects of fixation and demineralization on histomorphology and DNA amplification of canine bone marrow.Veterinary pathology · 2024Article
- Article
- A Synoptic Reporting System to Monitor Bone Marrow Aspirate and Biopsy Quality.Journal of pathology informatics · 2021Article
- Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Primary bone metastasis as first manifestation of an unknown primary tumour.BMJ case reports · 2015Article
- Bone marrow metastasis of prostatic adenocarcinoma with post-treatment foamy-like changes: A diagnostic pitfall.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2014Article
- Article
- [Bone marrow biopsy: processing and use of molecular techniques].Der Pathologe · 2012Review
- Aminobisphosphonate stimulates bone regeneration and enforces consolidation of titanium implant into a new rat caudal vertebrae model.Pathology oncology research : POR · 2009Article
- Diagnosis of unknown nonhematological tumors by bone marrow biopsy: a retrospective analysis of 10,112 samples.Journal of cancer research and clinical oncology · 2009Article
- Immunohistochemical evaluation of 95 bone marrow reactive plasmacytoses.Pathology oncology research : POR · 2009Article
- Role of CD138, CD56, and light chain immunohistochemistry in suspected and diagnosed plasma cell myeloma: A prospective study.South Asian journal of cancerArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specimens of bone marrow trephine biopsy (BMT) are transported and fixed in acetic acid-zinc-formalin fixative, decalcified in 10% formic acid-5% formaldehyde and processed with other specimens to paraffin-wax embedding. Sections, 1-microm-thick, are cut by experienced histotechnologists and used for haematoxylin and eosin, Giemsa, reticulin silver and other histological stains. Further, all immunohistochemical procedures used in the laboratory, including double immunostaining, can be used on these sections with no or minimal modifications. About 10,000 BMT specimens have been analysed using this procedure since 1997 and diseases involving the bone marrow have been classified successfully. More recently, standardised polymerase chain reaction-based analysis and mRNA in situ hybridisation studies have been conducted. Excellent morphology with good antigen, DNA and RNA preservation is offered by the Hammersmith Protocol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.