ArticleBiophysical journal2006
Time-resolved detection of conformational changes in oat phytochrome A: time-dependent diffusion.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Light-induced conformational changes in full-length Arabidopsis thaliana cryptochrome.Journal of molecular biology · 2011Article
- Light-induced conformational change and product release in DNA repair by (6-4) photolyase.Journal of the American Chemical Society · 2011Article
- Charge stabilization in reaction center protein investigated by optical heterodyne detected transient grating spectroscopy.European biophysics journal : EBJ · 2008Article
- Coarse-grained free energy functions for studying protein conformational changes: a double-well network model.Biophysical journal · 2007Article
- Photoreverse reaction dynamics of octopus rhodopsin.Biophysical journal · 2007Article
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Authors and funding
6 authors.
Funding
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Abstract
Conformational changes in oat phytochrome A (phy) in solution after photoexcitation of the red-absorbing form (Pr) were studied in time-domain by the pulsed laser-induced transient grating technique. It was found that the diffusion coefficient (D) of far-red-absorbing form (Pfr) of large phy (1.3 x 10(-11) m(2) s(-1)) is markedly reduced compared with that of Pr (5.8 x 10(-11) m(2) s(-1)). This large reduction indicates that the conformation of Pfr is significantly changed from that of Pr, so that the intermolecular interaction with water molecules increases. This change completes within 1 ms after the photoexcitation. On the other hand, D of Pr of intact phy (4.1 x 10(-11) m(2) s(-1)) first decreases upon photoexcitation to 0.89 x 10(-11) m(2) s(-1) within 1 ms and then gradually increases with a time constant of 100 ms to the value of Pfr, 1.7 x 10(-11) m(2) s(-1). This slower phase suggests that the conformation of the N-terminal region changes with 100 ms to decrease the intermolecular interaction with water after a global change in the large phy region. The increase of D was interpreted in terms of alpha-helix formation in the Pfr form from the random coil structure in the Pr form.
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