ArticlePLoS genetics2006
Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.Human molecular genetics · 2021Article
- A multi-batch design to deliver robust estimates of efficacy and reduce animal use - a syngeneic tumour case study.Scientific reports · 2020Article
- The effects of microchipping C57BL/6N mice on standard phenotyping tests.F1000Research · 2020Article
- Reproducible preclinical research-Is embracing variability the answer?PLoS biology · 2018Article
- A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5).Journal of anatomy · 2017Article
- Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography.Biomedical optics express · 2016Article
- Optical coherence tomography for embryonic imaging: a review.Journal of biomedical optics · 2016Review
- Automatic classification framework for ventricular septal defects: a pilot study on high-throughput mouse embryo cardiac phenotyping.Journal of medical imaging (Bellingham, Wash.) · 2015Article
- Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.Nature genetics · 2015Article
- Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy.Disease models & mechanisms · 2014Article
- Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.PloS one · 2014Article
- Prevention of LPS-induced microglia activation, cytokine production and sickness behavior with TLR4 receptor interfering peptides.PloS one · 2013Article
- The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- The fallacy of ratio correction to address confounding factors.Laboratory animals · 2012Article
- Structural and functional concepts in current mouse phenotyping and archiving facilities.Journal of the American Association for Laboratory Animal Science : JAALAS · 2012Article
- Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium.Disease models & mechanisms · 2012Article
- The phenotypic distribution of quantitative traits in a wild mouse F1 population.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.Behavioural brain research · 2012Article
- CreZOO--the European virtual repository of Cre and other targeted conditional driver strains.Database : the journal of biological databases and curation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Understanding mammalian genetic systems is predicated on the determination of the relationship between genetic variation and phenotype. Several international programmes are under way to deliver mutations in every gene in the mouse genome. The challenge for mouse geneticists is to develop approaches that will provide comprehensive phenotype datasets for these mouse mutant libraries. Several factors are critical to success in this endeavour. It will be important to catalogue assay and environment and where possible to adopt standardised procedures for phenotyping tests along with common environmental conditions to ensure comparable datasets of phenotypes. Moreover, the scale of the task underlines the need to invest in technological development improving both the speed and cost of phenotyping platforms. In addition, it will be necessary to develop new informatics standards that capture the phenotype assay as well as other factors, genetic and environmental, that impinge upon phenotype outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.