ArticlePLoS biology2006
Disruption-induced mucus secretion: repair and protection.
Article in PLoS biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Optimization ofInternational journal of molecular sciences · 2024Article
- Mucus-coated, magnetically-propelled fecal surrogate to mimic fecal shear forces on colonic epithelium.Biomaterials · 2024Article
- The Impact of Integrating a Low-Lectin Diet with Traditional ADHD Treatments on Gut Microbiota Composition and Symptom Improvement in Children - A Cohort Study.Neuropsychiatric disease and treatment · 2024Article
- Transient plasma membrane disruption induced calcium waves in mouse and human corneal epithelial cells.PloS one · 2024Article
- Magnetically-propelled fecal surrogates for modeling the impact of solid-induced shear forces on primary colonic epithelial cells.Biomaterials · 2021Article
- Mucus.Current biology : CB · 2021Article
- Review
- Plasma membrane integrity: implications for health and disease.BMC biology · 2021Review
- Transient Cell Membrane Disruptions induce Calcium Waves in Corneal Keratocytes.Scientific reports · 2020Article
- Imaging viscosity of intragranular mucin matrix in cystic fibrosis cells.Scientific reports · 2017Article
- IL-9 and Th9 in parasite immunity.Seminars in immunopathology · 2017Review
- Dynamic polymer systems with self-regulated secretion for the control of surface properties and material healing.Nature materials · 2015Article
- Probiotics, prebiotics and the gastrointestinal tract in health and disease.Inflammopharmacology · 2014Review
- Cell wounding activates phospholipase D in primary mouse keratinocytes.Journal of lipid research · 2013Article
- Acute oral ethanol exposure triggers asthma in cockroach allergen-sensitized mice.The American journal of pathology · 2012Article
- Diversity and dialogue in immunity to helminths.Nature reviews. Immunology · 2011Review
- Changes in cell morphology due to plasma membrane wounding by acoustic cavitation.Ultrasound in medicine & biology · 2010Article
- Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.Cell host & microbe · 2009Review
- Article
- Rehabilitation and the single cell.Current opinion in cell biology · 2007Review
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When a cell suffers a plasma membrane disruption, extracellular Ca(2+) rapidly diffuses into its cytosol, triggering there local homotypic and exocytotic membrane fusion events. One role of this emergency exocytotic response is to promote cell survival: the internal membrane thus added to the plasma membrane acts as a reparative "patch." Another, unexplored consequence of disruption-induced exocytosis is secretion. Many of the cells lining the gastrointestinal tract secrete mucus via a compound exocytotic mechanism, and these and other epithelial cell types lining the digestive tract are normally subject to plasma membrane disruption injury in vivo. Here we show that plasma membrane disruption triggers a potent mucus secretory response from stomach mucous cells wounded in vitro by shear stress or by laser irradiation. This disruption-induced secretory response is Ca(2+) dependent, and coupled to cell resealing: disruption in the absence of Ca(2+) does not trigger mucus release, but results instead in cell death due to failure to reseal. Ca(2+)-dependent, disruption-induced mucus secretion and resealing were also demonstrable in segments of intact rat large intestine. We propose that, in addition to promoting cell survival of membrane disruptions, disruption-induced exocytosis serves also the important protective function of liberating lubricating mucus at sites of mechanical wear and tear. This mode of mechanotransduction can, we propose, explain how lubrication in the gastrointestinal tract is rapidly and precisely adjusted to widely fluctuating, diet-dependent levels of mechanical stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.