ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2007
Interaction of psychological factors and the effect of epoetin-alfa treatment in cancer patients on hemoglobin and fatigue.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Cancer-related fatigue and its associations with depression and anxiety: a systematic review.PsychosomaticsPooled it
- Development and validation of a machine learning-based risk prediction model for cancer-related fatigue in ovarian cancer patients.Frontiers in oncology · 2026Article
- Epoetin alfa has a potent anxiolytic effect on naive female rats.BMC pharmacology & toxicology · 2025Article
- Fatigue and resting-state functional brain networks in breast cancer patients treated with chemotherapy.Breast cancer research and treatment · 2021Article
- The relationship between Type D personality, affective symptoms and hemoglobin levels in chronic heart failure.PloS one · 2013Article
- Is cancer-related fatigue more strongly correlated to haematological or to psychological factors in cancer patients?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION AND
backgroundEpoetin alpha is known to produce a hematological response in anemic cancer patients. A concomitant reduction in fatigue as well as an improvement of depression and anxiety and of quality of life has been reported. However, these effects are discussed controversially. Psychological variables may have a moderating effect on fatigue reduction. MATERIALS AND
methodsFifty-four anemic cancer outpatients were treated with epoetin alpha over 26 weeks with an initial dose of 3 x 10,000 IU/week and further individually adapted dosage. Hemoglobin level, fatigue, depression, anxiety, and health-related quality of life were measured every 4 weeks.
resultsThe hematological response rate was 50%, with 1/3 occurring after more than 8 weeks of treatment. Fatigue, depression, and quality of life improved significantly. Reduction in fatigue was associated with response, but the correlations between fatigue and hemoglobin were weak. Less depression and higher quality of life before treatment correlated with a better fatigue reduction when controlling for hemoglobin increase and initial fatigue level.
conclusionPsychological variables influence the reduction of fatigue during therapy with epoetin alpha in anemic cancer patients and should therefore be assessed at the beginning of treatment.
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