ArticleHistochemistry and cell biology2007
Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes.
Article in Histochemistry and cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.Comparative medicine · 2013Article
- Hereditary hemochromatosis and transferrin receptor 2.Biochimica et biophysica acta · 2012Review
- Iron metabolism: current facts and future directions.Biochemia medica · 2012Review
- Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo.Haematologica · 2011Article
- Iron regulation by hepatocytes and free radicals.Journal of clinical biochemistry and nutrition · 2011Article
- Transferrin-directed internalization and cycling of transferrin receptor 2.Traffic (Copenhagen, Denmark) · 2009Article
- A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.Neurobiology of disease · 2009Article
- Characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses.Journal of virological methods · 2009Article
- Iron metabolism in the eye: a review.Experimental eye research · 2009Review
- [Hereditary hemochromatosis, alpha-1-antitrypsin deficiency and Wilson's disease. Pathogenesis, clinical findings and pathways to diagnosis].Der Pathologe · 2008Article
- Recent progress in histochemistry.Histochemistry and cell biology · 2007Review
- The histochemistry and cell biology vade mecum: a review of 2005-2006.Histochemistry and cell biology · 2006Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The newly discovered proteins hemojuvelin (Hjv) and transferrin receptor type 2 (TfR2) are involved in iron metabolism. Mutations in the Hjv and TfR2 gene cause hemochromatosis. We investigated the expression and cellular localization of Hjv and TfR2 in rat and human liver. The expression of Hjv and TfR2 was shown on mRNA and protein level by RT-PCR and immunoblot experiments. Their cellular localization was studied by immunofluorescence with antibodies raised against Hjv and TfR2. Hjv and TfR2 are present in human and rat liver and in primary human hepatocytes. Antisera raised against Hjv identified immunoreactive proteins with an apparent size of 44 and 46 kDa in immunoblot experiments of rat and human liver extracts, which are in accordance with the putative membrane-bound and cleaved soluble forms of this protein, respectively. TfR2 was detected as a 105 kDa protein corresponding to the predicted size of glycosylated TfR2 monomers. In immunofluorescence experiments, Hjv and TfR2 were found in rat liver only in hepatocytes. At the subcellular level, both proteins were predominantly localized to the basolateral membrane domain of hepatocytes. The localization of Hjv and TfR2 at the same membrane domain renders a functional interaction of these two proteins in iron homeostasis possible.
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