ReviewPediatric nephrology (Berlin, Germany)2007
Role of fibroblast growth factor receptor signaling in kidney development.
Review in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- DNA hypermethylation of FGFR2 drives fibrosis in the aging kidney.Scientific reports · 2026Article
- Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance.Biomolecules · 2024Review
- The multifaceted links between hearing loss and chronic kidney disease.Nature reviews. Nephrology · 2024Review
- FGF10 Protects Against Renal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammatory Signaling.Frontiers in genetics · 2018Article
- Gene, cell, and organ multiplication drives inner ear evolution.Developmental biology · 2017Review
- Mosaic analysis of cell rearrangements during ureteric bud branching in dissociated/reaggregated kidney cultures and in vivo.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Proteomic analysis of embryonic kidney development: Heterochromatin proteins as epigenetic regulators of nephrogenesis.Scientific reports · 2015Article
- Signaling during Kidney Development.Cells · 2015Review
- Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.Pediatric nephrology (Berlin, Germany) · 2014Review
- Signal transduction in podocytes--spotlight on receptor tyrosine kinases.Nature reviews. Nephrology · 2014Review
- Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.Journal of the American Society of Nephrology : JASN · 2013Article
- Article
- FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.Developmental cell · 2012Article
- Progesterone inhibits uterine gland development in the neonatal mouse uterus.Biology of reproduction · 2012Article
- Mutational activation of FGFR3: no involvement in the development of renal cell carcinoma.Journal of cancer research and clinical oncology · 2012Article
- Renal collecting system growth and function depend upon embryonic γ1 laminin expression.Development (Cambridge, England) · 2011Article
- FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype.BMC research notes · 2011Article
- Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney.Development (Cambridge, England) · 2011Article
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits fibroblast growth factor 10-induced prostatic bud formation in mouse urogenital sinus.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.Development (Cambridge, England) · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Fibroblast growth factor receptors (Fgfrs) are expressed in the ureteric bud and metanephric mesenchyme of the developing kidney. Furthermore, in vitro and in vivo studies have shown that exogenous fibroblast growth factors (Fgfs) increase growth and maturation of the metanephric mesenchyme and ureteric bud. Deletion of fgf7, fgf10, and fgfr2IIIb (the receptor isoform that binds Fgf7 and Fgf10) in mice lead to smaller kidneys with fewer collecting ducts and nephrons. Overexpression of a dominant negative receptor isoform in transgenic mice has revealed more striking defects including renal aplasia or severe dysplasia. Moreover, deletion of many fgf ligands and receptors in mice results in early embryonic lethality, making it difficult to determine their roles in kidney development. Recently, conditional targeting approaches revealed that deletion of fgf8 from the metanephric mesenchyme interrupts nephron formation. Furthermore, deletion of fgfr2 from the ureteric bud resulted in both ureteric bud branching and stromal mesenchymal patterning defects. Deletion of both fgfr1 and fgfr2 in the metanephric mesenchyme resulted in renal aplasia, characterized by defects in metanephric mesenchyme formation and initial ureteric bud elongation and branching. Thus, Fgfr signaling is critical for growth and patterning of all renal lineages at early and later stages of kidney development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.