ReviewCell cycle (Georgetown, Tex.)2006
Spatial segregation of Ras signaling: new evidence from fission yeast.
Review in Cell cycle (Georgetown, Tex.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.Cell reports · 2015Article
- Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans.Eukaryotic cell · 2015Article
- Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.Molecular and cellular biology · 2014Article
- A bimolecular fluorescent complementation screen reveals complex roles of endosomes in Ras-mediated signaling.Methods in enzymology · 2014Article
- Article
- CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling.Oncogene · 2012Article
- Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus.Eukaryotic cell · 2012Article
- Ras trafficking, localization and compartmentalized signalling.Seminars in cell & developmental biology · 2012Review
- Busy traveling Ras.Cell cycle (Georgetown, Tex.) · 2011Article
- Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies.Molecular and cellular biology · 2011Article
- Ras and Nox: Linked signaling networks?Free radical biology & medicine · 2009Review
- A predicted interactome for Arabidopsis.Plant physiology · 2007Article
- Article
- Escorting Ras.Small GTPasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Ras GTPases act as binary switches for signal transduction pathways that are important for growth regulation and tumorigenesis. Despite the biochemical simplicity of this switch, Ras proteins control multiple pathways, and the functions of the four mammalian Ras proteins are not overlapping. This raises an important question--how does a Ras protein selectively regulate a particular activity? One recently emerging model suggests that a single Ras protein can control different functions by acting in distinct cellular compartments. A critical test of this model is to identify pathways that are selectively controlled by Ras when it is localized to a particular compartment. A recent study has examined Ras signaling in the fission yeast Schizosaccharomyces pombe, which expresses only one Ras protein that controls two separate evolutionarily conserved pathways. This study demonstrates that whereas Ras localized to the plasma membrane selectively regulates a MAP kinase pathway to mediate mating pheromone signaling, Ras localized to the endomembrane activates a Cdc42 pathway to mediate cell polarity and protein trafficking. This study has provided unambiguous evidence for compartmentalized signaling of Ras.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.