ReviewMolecular biology reports1990
Prosomes, subcomplexes of untranslated mRNP.
Review in Molecular biology reports, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 65 citations in OpenAlex.
- Bioinformatic identification of novel elements potentially involved in messenger RNA fate control during spermatogenesis.Biology of reproduction · 2012Article
- Prosomes (proteasomes) changes during differentiation are related to the type of inducer.Molecular biology reports · 1997Review
- Article
- Roles of proteasomes in cell growth.Molecular biology reports · 1995Review
- Phylogenic relationships of the amino acid sequences of prosome (proteasome, MCP) subunits.Molecular & general genetics : MGG · 1994Article
- JIPs and RIPs: the regulation of plant gene expression by jasmonates in response to environmental cues and pathogens.The Plant cell · 1994Review
- Nucleocytoplasmic transport.The Biochemical journal · 1994Review
- Free, cytoskeletal-bound and membrane-bound polysomes isolated from MPC-11 and Krebs II ascites cells differ in their complement of poly(A) binding proteins.Molecular and cellular biochemistry · 1994Article
- The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family.Molecular & general genetics : MGG · 1993Article
- Disruption of prosomes by some bivalent metal ions results in the loss of their multicatalytic proteinase activity and cancels the nuclease resistance of prosomal RNA.The Biochemical journal · 1992Article
- Subunit stoichiometry and three-dimensional arrangement in proteasomes from Thermoplasma acidophilum.The EMBO journal · 1992Article
- High-molecular-mass multicatalytic proteinase complexes produced by the nitrogen-fixing actinomycete Frankia strain BR.Journal of bacteriology · 1992Article
- Interaction between mRNA, ribosomes and the cytoskeleton.The Biochemical journal · 1991Review
- Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.The EMBO journal · 1991Article
- Regulation of apoptosis by the ubiquitin and proteasome pathway.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PROSOMES are a novel class of small RNP particles of uniform morphology, but of variable RNA (pRNA) and protein composition (about 650,000 MW; 12 nm diameter in the EM). They were discovered as subcomplexes of free mRNP, tightly attached to inactive mRNA in the cytoplasm. The pRNAs hybridize stably to mRNA. Prosomes associate in vitro to mRNA and inhibit cell free protein synthesis inducing an mRNA structure unable to interact with ribosomes. Many types of prosomes were observed. The individual particle is made up by a variable combination of about 20 characteristic proteins and one or several pRNa. Some prosomal proteins are glycosylated, phosphorylated and, possibly, ADP-ribosylated and are highly conserved in evolution whilst others vary with the species and the mRNA population they are associated to. A protease activity was found associated to prosomes. The function(s) of the prosomes is(are) still unknown. The differential inhibition of in vitro protein synthesis points to a capacity to recognize mRNA and to keep it in an inactive state. The observation with the aid of monoclonal antibodies (pMABs) that prosomes and thus mRNP are attached to the intermediate filaments (IF) raises the question if one of the functions of the IF might be in the topological distribution of mRNA within the cell. Similar to the cytokeratin fibers, the prosome networks bridge neighboring cells at specific positions. The nucleus also contains some prosomal antigens, located on chromosomes and on the nuclear matrix. Their presence and distribution in the cell compartments varies with the cell type and the prosomal antigen probed. Oocytes contain large amounts of prosomes.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.