ArticleBlood2006
BCR ubiquitination controls BCR-mediated antigen processing and presentation.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- SorLA regulates B cell receptor uptake, trafficking, and B cell-mediated immune responses in vivo.The Journal of experimental medicine · 2026Article
- B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells.International journal of molecular sciences · 2023Review
- The Ins and Outs of Antigen Uptake in B cells.Frontiers in immunology · 2022Review
- Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The immunobiology of ubiquitin-dependent B cell receptor functions.Molecular immunology · 2018Review
- Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.Clinical reviews in allergy & immunology · 2017Review
- Cocapture of cognate and bystander antigens can activate autoreactive B cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Proteasome inhibitors as experimental therapeutics of autoimmune diseases.Arthritis research & therapy · 2015Review
- Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells.Frontiers in immunology · 2014Review
- How B cells capture, process and present antigens: a crucial role for cell polarity.Nature reviews. Immunology · 2013Review
- The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation.The Journal of biological chemistry · 2012Article
- Physiological-range temperature changes modulate cognate antigen processing and presentation mediated by lipid raft-restricted ubiquitinated B cell receptor molecules.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Practical considerations on the use of rituximab in autoimmune neurological disorders.Therapeutic advances in neurological disorders · 2010Article
- Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages.Infection and immunity · 2009Article
- Dynamics of membrane trafficking downstream of B and T cell receptor engagement: impact on immune synapses.Traffic (Copenhagen, Denmark) · 2009Review
- B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases.Advances in immunology · 2008Review
- The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.The Journal of cell biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BCR-mediated antigen processing occurs at immunologically relevant antigen concentrations and hinges on the trafficking of antigen-BCR (Ag-BCR) complexes to class II-containing multivesicular bodies (MVBs) termed MIICs. However, the molecular mechanism underlying the trafficking of Ag-BCR complexes to and within MIICs is not well understood. In contrast, the trafficking of the epidermal growth factor receptor (EGFR) to and within MVBs occurs via a well-characterized ubiquitin-dependent mechanism, which is blocked by acute inhibition of proteasome activity. Using a highly characterized antigen-specific model system, it was determined that the immunoglobulin heavy chain subunit of the IgM BCR of normal (ie, nontransformed) B cells is ubiquitinated. Moreover, acute inhibition of proteasome activity delays the formation of ubiquitinated ligand-BCR complexes, alters the intracellular trafficking of internalized Ag-BCR complexes, and selectively blocks the BCR-mediated processing and presentation of cognate antigen, without inhibiting the endocytosis, processing, and presentation of non-cognate antigen internalized by fluidphase endocytosis. These results demonstrate that the trafficking of Ag-BCR complexes to and within MVB-like antigen processing compartments occurs via a molecular mechanism with similarities to that used by the EGFR, and establishes the EGFR as a paradigm for the further analysis of Ag-BCR trafficking to and within MIICs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.