ArticleThe Journal of physiology2006
Turning off cortical ensembles stops striatal Up states and elicits phase perturbations in cortical and striatal slow oscillations in rat in vivo.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Acute fentanyl and xylazine co-exposure uniquely increase the excitability of dopamine type 2 receptor-expressing striatal medium spiny neurons.Journal of neurophysiology · 2026Article
- Attractor and integrator networks in the brain.Nature reviews. Neuroscience · 2022Review
- Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity.Nature communications · 2020Article
- Striatal network modeling in Huntington's Disease.PLoS computational biology · 2020Article
- Neuropilin 2 Signaling Mediates Corticostriatal Transmission, Spine Maintenance, and Goal-Directed Learning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain.Neuroscience · 2019Article
- An Integrated Model of Action Selection: Distinct Modes of Cortical Control of Striatal Decision Making.Annual review of psychology · 2019Article
- Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures.Scientific reports · 2018Article
- Exercise-Induced Neuroprotection of the Nigrostriatal Dopamine System in Parkinson's Disease.Frontiers in aging neuroscience · 2017Review
- Loss of Homeostasis in the Direct Pathway in a Mouse Model of Asymptomatic Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Temporal correlations among functionally specialized striatal neural ensembles in reward-conditioned mice.Journal of neurophysiology · 2016Article
- Article
- Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates.Journal of neurophysiology · 2013Article
- Optogenetic identification of striatal projection neuron subtypes during in vivo recordings.Brain research · 2013Review
- Optimal balance of the striatal medium spiny neuron network.PLoS computational biology · 2013Article
- Populations of striatal medium spiny neurons encode vibrotactile frequency in rats: modulation by slow wave oscillations.Journal of neurophysiology · 2013Article
- Input dependent cell assembly dynamics in a model of the striatal medium spiny neuron network.Frontiers in systems neuroscience · 2012Article
- Enhanced high-frequency membrane potential fluctuations control spike output in striatal fast-spiking interneurones in vivo.The Journal of physiology · 2011Article
- Synaptically driven state transitions in distal dendrites of striatal spiny neurons.Nature neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In vivo, cortical neurons and striatal medium spiny neurons (MSN) display robust subthreshold depolarizations (Up states) during which they are enabled to fire action potentials. In the cortex, Up states are believed to occur simultaneously in a neuronal ensemble and to be sustained by local network interactions. It is known that MSN are impelled into the Up state by extra-striatal (primarily cortical) inputs, but the mechanisms that sustain and determine the end of striatal Up states are still debated. Furthermore, it has not been established if brisk perturbations of ongoing cortical oscillations alter rhythmic transitions between Up and Down states in striatal neurons. Here we report that MSN Up states terminate abruptly when persistent activity in cortical ensembles providing afferents to a given striatal region is turned off by local electrical stimulation or ends spontaneously. In addition, we found that phase perturbations in MSN membrane potential slow oscillations induced by cortical stimulation replicate the stimulus-induced dynamics of spiking activity in cortical ensembles. Overall, these results suggest that striatal Up states are single-cell subthreshold representations of episodes of persistent spiking in cortical ensembles. A precise spatial and temporal alignment between episodes of cortical persistent activity and striatal Up states would allow MSN to detect specific cortical inputs embedded within a more general cortical signal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.