Trial reportThe Journal of physiology2006
Peripheral amplification of sweating--a role for calcitonin gene-related peptide.
Trial report in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.CNS drugs · 2012Pooled it
- Exploring the mechanisms underpinning sweating: the development of a specialized ventilated capsule for use with intradermal microdialysis.Physiological reports · 2016Trial
- Aerobic training improves in vivo cholinergic responsiveness but not sensitivity of eccrine sweat glands.The Journal of investigative dermatology · 2010Trial
- Comprehensive Mechanisms and Non-Invasive Treatment for Complex Regional Pain Syndrome: A Narrative Review.Journal of pain research · 2025Review
- Primary hyperhidrosis: From a genetics point of view.Journal of family medicine and primary care · 2023Review
- The Role of Neuroinflammation in Complex Regional Pain Syndrome: A Comprehensive Review.Journal of pain research · 2023Review
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- From a Symptom-Based to a Mechanism-Based Pharmacotherapeutic Treatment in Complex Regional Pain Syndrome.Drugs · 2022Review
- TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases.Frontiers in molecular biosciences · 2022Review
- Molecular Aspects of Regional Pain Syndrome.Pain research & management · 2020Review
- Complex regional pain syndrome: a focus on the autonomic nervous system.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Separate and combined effects of KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Review
- Complex regional pain syndrome-up-to-date.Pain reports · 2017Article
- Neuropeptide PACAP promotes sweat secretion.The British journal of dermatology · 2017Article
- Intradermal administration of atrial natriuretic peptide has no effect on sweating and cutaneous vasodilator responses in young male adults.Temperature (Austin, Tex.) · 2017Article
- [Complex regional pain syndrome following distal fractures of the radius : Epidemiology, pathophysiological models, diagnostics and therapy].Der Unfallchirurg · 2016Review
- Skin sympathetic function in complex regional pain syndrome type 1.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Article
- Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Eccrine sweat gland development and sweat secretion.Experimental dermatology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptides are the mediators of neurogenic inflammation. Some pain disorders, e.g. complex regional pain syndromes, are characterized by increased neurogenic inflammation and by exaggerated sudomotor function. The aim of this study was to explore whether neuropeptides have a peripheral effect on human sweating. We investigated the effects of different concentrations of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and substance P (SP) on acetylcholine-induced axon reflex sweating in healthy subjects (total n = 18). All substances were applied via dermal microdialysis. The experiments were done in a parallel setting: ACh alone and ACh combined with CGRP, VIP or SP in various concentrations were applied. Acetylcholine (10(-2) m) always elicited a sweating response, neuropeptides alone did not. However, CGRP significantly enhanced ACh-induced sweating (P < 0.01). Post hoc tests revealed that CGRP in physiological concentrations of 10(-7)-10(-9) m was most effective. VIP at any concentration had no significant effect on axon reflex sweating. The duration of the sweating response (P < 0.01), but not the amount of sweat, was reduced by SP. ACh-induced skin blood flow was significantly increased by CGRP (P < 0.01), but unaltered by VIP and SP. The results indicate that CGRP amplifies axon reflex sweating in human skin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.