ArticleThe Journal of physiology2006
The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Anticipatory changes in human motoneuron discharge patterns during motor preparation.The Journal of physiology · 2008Trial
- Spinal motoneuron excitability is homeostatically regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice.Progress in neurobiology · 2026Article
- Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons.Frontiers in molecular neuroscience · 2022Article
- Synaptic disruption and CREB-regulated transcription are restored by KEMBO molecular medicine · 2021Article
- Retracing your footsteps: developmental insights to spinal network plasticity following injury.Journal of neurophysiology · 2018Review
- Article
- SK channel inhibition mediates the initiation and amplitude modulation of synchronized burst firing in the spinal cord.Journal of neurophysiology · 2017Article
- Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice.Journal of neurophysiology · 2015Article
- Article
- Changes in motoneuron afterhyperpolarization duration in stroke survivors.Journal of neurophysiology · 2014Article
- Dynamic remodeling of the guinea pig intrinsic cardiac plexus induced by chronic myocardial infarction.Autonomic neuroscience : basic & clinical · 2014Article
- The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons.Frontiers in computational neuroscience · 2014Article
- Differential contributions of somatic and dendritic calcium-dependent potassium currents to the control of motoneuron excitability following spinal cord injury.Cognitive neurodynamics · 2012Article
- Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Deciphering the contribution of intrinsic and synaptic currents to the effects of transient synaptic inputs on human motor unit discharge.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2010Review
- Characteristics and organization of discharge properties in rat hindlimb motoneurons.Journal of neurophysiology · 2010Article
- Motoneuron excitability: the importance of neuromodulatory inputs.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2009Review
- Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Summation of excitatory and inhibitory synaptic inputs by motoneurons with highly active dendrites.Journal of neurophysiology · 2008Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Does the afterhyperpolarization current control the gain and discharge variability of motoneurones according to the same law? We investigated this issue in lumbar motoneurones of anaesthetized cats. Using dynamic clamp, we measured the conductance, time constant and driving force of the AHP current in a sample of motoneurones and studied how the gain was correlated to these quantities. To study the action of the AHP on the discharge variability and to compare it to its action on the gain, we injected an artificial AHP-like current in motoneurones. This increased the natural AHP. In three motoneurones, we abolished most of the natural AHP with the calcium chelator BAPTA to investigate the condition where the discharge was essentially controlled by the artificial AHP. Our results demonstrate that both the gain and the coefficient of variation of the firing rate are inversely proportional to the magnitude and to the time constant of the artificial AHP conductance. This indicates that the AHP exerts the same control over the gain and the variability. This mechanism ensures that the variability of the discharge is modulated with the gain. This guarantees a great regularity of the discharge when the motoneurone is in a low excitability state and hence good control of the force produced.
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