ArticleMedical & biological engineering & computing2006
Control oriented model of insulin and glucose dynamics in type 1 diabetics.
Article in Medical & biological engineering & computing, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Stochastic virtual population in type 1 diabetes.PloS one · 2026Article
- A simple modeling framework for prediction in the human glucose-insulin system.Chaos (Woodbury, N.Y.) · 2023Article
- Mathematical Models of Meal Amount and Timing Variability With Implementation in the Type-1 Diabetes Patient Decision Simulator.Journal of diabetes science and technology · 2021Article
- ChatteringIET systems biology · 2020Article
- Mathematical Modeling for the Physiological and Clinical Investigation of Glucose Homeostasis and Diabetes.Frontiers in physiology · 2020Review
- Simulation Software for Assessment of Nonlinear and Adaptive Multivariable Control Algorithms: Glucose - Insulin Dynamics in Type 1 Diabetes.Computers & chemical engineering · 2019Article
- Control Limitations in Models of T1DM and the Robustness of Optimal Insulin Delivery.Journal of diabetes science and technology · 2018Article
- Personalized glucose forecasting for type 2 diabetes using data assimilation.PLoS computational biology · 2017Article
- A comprehensive compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects.Medical & biological engineering & computing · 2016Article
- Dynamical phenotyping: using temporal analysis of clinically collected physiologic data to stratify populations.PloS one · 2014Article
- Non-invasive continuous glucose monitoring: improved accuracy of point and trend estimates of the Multisensor system.Medical & biological engineering & computing · 2012Article
- Population physiology: leveraging electronic health record data to understand human endocrine dynamics.PloS one · 2012Article
- Observer-based state feedback for enhanced insulin control of type 'i' diabetic patients.The open biomedical engineering journal · 2011Article
- A robust sliding mode controller with internal model for closed-loop artificial pancreas.Medical & biological engineering & computing · 2010Article
- Multi-objective blood glucose control for type 1 diabetes.Medical & biological engineering & computing · 2009Article
- Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus.Clinical pharmacokinetics · 2008Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to realize a mathematical model of insulin-glucose relationship in type I diabetes and test its effectiveness for the design of control algorithms in external artificial pancreas. A new mathematical model, divided into glucose and insulin sub-models, was developed from the so-called "minimal model". The key feature is the representation of insulin sensitivity so as to permit the personalisation of the parameters. Real-time applications are based on an insulin standardised model. Clinical data were used to estimate model parameters. Root mean square error between simulated and real blood glucose profiles (G(rms)) was used to evaluate system efficacy. Results from parameter estimation and insulin standardisation showed a good capability of the model to identify individual characteristics. Simulation results with a G(rms) 1.30 mmol/l in the worst case testified the capacity of the model to accurately represent glucose-insulin relationship in type 1 diabetes allowing self tuning in real time.
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16929923What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.