ArticleJournal of perinatology : official journal of the California Perinatal Association2006
Hyperglycemia and morbidity and mortality in extremely low birth weight infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06647537 (Frequency of Neonatal Hyperglycemia at Assuit University Children Hospital), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Frequency of Neonatal Hyperglycemia at Assuit University Children Hospital
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Long-Term Outcomes after Early Neonatal Hyperglycemia in VLBW Infants: A Systematic Review.Neonatology · 2021Pooled it
- Interventions for prevention of neonatal hyperglycemia in very low birth weight infants.The Cochrane database of systematic reviews · 2011Pooled it
- Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk.Pediatric research · 2024Trial
- Intranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats.Developmental neuroscience · 2022Trial
- Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial.The Lancet. Child & adolescent health · 2021Trial
- Pilot study of a model-based approach to blood glucose control in very-low-birthweight neonates.BMC pediatrics · 2012Trial
- Randomized trial of sterile water by gavage drip in the fluid management of extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2009Trial
- A randomised controlled trial of early insulin therapy in very low birth weight infants, "NIRTURE" (neonatal insulin replacement therapy in Europe).BMC pediatrics · 2007Trial
- The neonatal continuous glucose monitoring paradox: why at-risk infants still lack access to a transformative technology-A call for needs-led innovation.Frontiers in medicine · 2026Article
- Early glucose and sodium trajectories and short-term outcomes in extremely preterm infants.Frontiers in pediatrics · 2026Article
- Evidence and unknowns for the relevancy of applying current parenteral nutrition support recommendations among infants born less than 750 g or younger than 25 weeks' gestation: A narrative review.JPEN. Journal of parenteral and enteral nutrition · 2025Review
- Management of Neonatal Hyperglycaemia in Sweden-A Survey Study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Treatment of Severe Hyperglycemia in Extremely Preterm Infants Using Continuous Subcutaneous Insulin TherapyJournal of clinical research in pediatric endocrinology · 2024Article
- The Vagus Nerve Regulates Immunometabolic Homeostasis in the Ovine Fetus near Term: The Impact on Terminal Ileum.Biology · 2024Article
- A Higher Amount of Nutritional Intake as a Possible Cause of Hyperglycemia in Extremely Premature Infants in Parenteral and Enteral Nutrition at the Tertiary Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2023Article
- Hyperglycemia and prematurity: a narrative review.Pediatric research · 2023Review
- Review: Nutritional regulation of muscle growth in neonatal swine.Animal : an international journal of animal bioscience · 2023Review
- Blood Glucose, Lactate and Platelet Count in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis-A Pilot Study.Children (Basel, Switzerland) · 2023Article
- Neonatal Hyperglycemia and Neurodevelopmental Outcomes in Preterm Infants: A Review.Children (Basel, Switzerland) · 2022Review
- Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to determine the association between hyperglycemia and mortality and late-onset infections (>72 h) in extremely low birth weight (ELBW) infants. STUDY
designRetrospective analysis of a prospective cohort study of 201 ELBW infants who survived greater than 3 days after birth. Mean morning glucose levels were categorized as normoglycemia (<120 mg/dl), mild-moderate hyperglycemia (120 to 179 mg/dl) and severe hyperglycemia (> or =180 mg/dl). Hyperglycemia was further divided into early (first 3 days of age) and persistent (first week of age). Logistic regression was performed to assess whether hyperglycemia was associated with either mortality or late-onset culture-proven infection, measured after 3 and 7 days of age.
resultsAdjusting for age, the odds ratio (OR) for either dying or developing a late infection was 5.07 (95% confidence interval (CI): 1.06 to 24.3) for infants with early severe hyperglycemia and 6.26 (95% CI: 0.73 to 54.0) for infants with persistent severe hyperglycemia. Adjusting for age, both severe early and persistent hyperglycemia were associated with increased mortality. Among survivors, there was no significant association between hyperglycemia and length of mechanical ventilation or length of hospital stay. Persistent severe hyperglycemia was associated with the development of Stage II/III necrotizing enterocolitis, after adjusting for age and male gender (OR: 9.49, 95% CI: 1.52 to 59.3).
conclusionSevere hyperglycemia in the first few days after birth is associated with increased odds of death and sepsis in ELBW infants.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.